(thiomorpholin-4-ylmethanediyl)bis(phosphonic acid)

Base Information

• Chemical Name: (thiomorpholin-4-ylmethanediyl)bis(phosphonic acid)
• CAS No.: 111072-49-2
• Molecular Formula: C₅H₁₃NO₆P₂S
• Molecular Weight: 277.175
• Mol file: 111072-49-2.mol

Synonyms:Phosphonicacid, (4-thiomorpholinylmethylene)bis- (9CI); Thiomorpholine, phosphonic acidderiv.

Chemical Property of (thiomorpholin-4-ylmethanediyl)bis(phosphonic acid)

Chemical Property:

• Vapor Pressure: 5.98E-16mmHg at 25°C
• Boiling Point: 600.1°C at 760 mmHg
• Flash Point: 316.7°C
• Density: 1.795g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (thiomorpholin-4-ylmethanediyl)bis(phosphonic acid)

There total 3 articles about (thiomorpholin-4-ylmethanediyl)bis(phosphonic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Thiomorpholin (123-90-0) → 4-thiomorpholinylmethylene-1,1-bisphosphonate (111072-49-2)

Guidance literature:

Thiomorpholin; trialkyl orthoformate; at 80 - 120 ℃;

With hydrogenchloride; In water; Reflux;

DOI:10.1016/j.ica.2015.05.034

Reference yield:

N-formyl-thiomorpholine (61907-20-8) + oxalyl dichloride (79-37-8) → 4-thiomorpholinylmethylene-1,1-bisphosphonate (111072-49-2)

Guidance literature:

With hydrogenchloride; triethyl phosphite; In dichloromethane; acetone;

Reference yield:

[(diethoxy-phosphoryl)-thiomorpholin-4-yl-methyl]-phosphonic acid diethyl ester → 4-thiomorpholinylmethylene-1,1-bisphosphonate (111072-49-2)

Guidance literature:

With hydrogenchloride; at 120 ℃;

DOI:10.1021/jm030084x

upstream raw materials:

N-formyl-thiomorpholine

oxalyl dichloride

Thiomorpholin