Card-20(22)-enolide,3,5,14-trihydroxy-,(3â,- 5â,17R)-

Base Information

• Chemical Name: Card-20(22)-enolide,3,5,14-trihydroxy-,(3â,- 5â,17R)-
• CAS No.: 4433-58-3
• Molecular Formula: C₂₃H₃₄O₅
• Molecular Weight: 390.52
• Mol file: 4433-58-3.mol

Synonyms:

Chemical Property of Card-20(22)-enolide,3,5,14-trihydroxy-,(3â,- 5â,17R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Card-20(22)-enolide,3,5,14-trihydroxy-,(3â,- 5â,17R)-

There total 35 articles about Card-20(22)-enolide,3,5,14-trihydroxy-,(3â,- 5â,17R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

Sucrose (57-50-1) + (+)-digitoxigenin (143-62-4) → 3-epi-periplogenin (71884-72-5) + digitoxigenin 3-O-β-D-glucoside (17059-16-4) + periplogenin glucoside (18531-44-7) + 4-[(3S,5S,8R,9S,10R,13R,14S,17S)-5,14-Dihydroxy-10,13-dimethyl-3-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one + (17β)-H-periplogenin (4433-58-3) + periplogenin (514-39-6,4433-58-3,71884-72-5,107596-70-3,117020-71-0)

Guidance literature:

With Tween 80; F₈ cells; In various solvent(s); at 25 ℃; for 360h; Product distribution; other reagents, reaction time;

DOI:10.1016/S0031-9422(97)00748-6

Reference yield: 37.0%

Sucrose (57-50-1) + (+)-digitoxigenin (143-62-4) → 3-epi-periplogenin (71884-72-5) + digitoxigenin 3-O-β-D-glucoside (17059-16-4) + periplogenin glucoside (18531-44-7) + 4-[(3S,5S,8R,9S,10R,13R,14S,17S)-5,14-Dihydroxy-10,13-dimethyl-3-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one + (17β)-H-periplogenin (4433-58-3) + periplogenin (514-39-6,4433-58-3,71884-72-5,107596-70-3,117020-71-0)

Guidance literature:

With Tween 80; F₈ cells; In various solvent(s); at 25 ℃; for 360h; Product distribution; other reagents, reaction time;

DOI:10.1016/S0031-9422(97)00748-6

Reference yield: 17.9%

(+)-digitoxigenin (143-62-4) → digitoxigenin 3-O-β-D-glucoside (17059-16-4) + periplogenin glucoside (18531-44-7) + 3α,14-dihydroxy-5β,14β-card-20(22)-enolide (545-52-8) + periplogenin (514-39-6,4433-58-3,71884-72-5,107596-70-3,117020-71-0)

Guidance literature:

With B₂K agar medium; Panax ginseng C_. A_. Meyer cells; In various solvent(s); at 25 ℃; for 456h; Further byproducts given;

DOI:10.1016/0031-9422(96)00079-9

upstream raw materials:

Sucrose

(+)-digitoxigenin

neridiginoside

digitoxigenin

Downstream raw materials:

periplogenin glucoside

14-hydroxy-14β-carda-3,5,20(22)-trienolide

Refernces

• 1、 Yoshikawa, Masayuki,Murakami, Toshiyuki,Shimada, Hiromi,Fukada, Nobuyuki,Matsuda, Hisashi,Sashida, Yutaka,Yamahara, Johji. "Corchorusosides A, B, C, D, and E, new cardiotonic oligoglycosides from the seeds of Corchorus olitorius L. (Moroheiya)". . p. 869 - 873. Retrieved 2007/10/03.
• 2、 Srivastava, Suman,Khare, Maheshwari P.,Khare, Anakshi. "CARDENOLIDE DIGLYCOSIDES FROM OXYSTELMA ESCULENTUM". . p. 1019 - 1022. Retrieved 2007/10/02.