6-Methyl-5-nitropyridine-2-carbaldehyde

Base Information

• Chemical Name: 6-Methyl-5-nitropyridine-2-carbaldehyde
• CAS No.: 25033-74-3
• Molecular Formula: C₇H₆N₂O₃
• Molecular Weight: 166.136
• DSSTox Substance ID: DTXSID20179742
• Wikidata: Q83050265
• Mol file: 25033-74-3.mol

Synonyms:6-methyl-5-nitropyridine-2-carbaldehyde;25033-74-3;6-Methyl-5-nitropicolinaldehyde;Picolinaldehyde, 6-methyl-5-nitro-;5-nitro-6-methyl-2-pyridinecarbaldehyde;SCHEMBL3257706;DTXSID20179742;NKZIEDOFORWCFI-UHFFFAOYSA-N;MFCD00466068;AKOS006274747;SB15980;SY248339;6-methyl-5-nitropyridine-2-carboxaldehyde;CS-0056699;FT-0757479;P10126;AN-584/40151720

Chemical Property of 6-Methyl-5-nitropyridine-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.00238mmHg at 25°C
• Boiling Point: 288.2°C at 760 mmHg
• Flash Point: 128.1°C
• PSA: 75.78000
• Density: 1.356g/cm³
• LogP: 1.63390
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 166.03784206
• Heavy Atom Count: 12
• Complexity: 190

Purity/Quality:

99% ^*data from raw suppliers

6-Methyl-5-nitropicolinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)C=O)[N+](=O)[O-]

Technology Process of 6-Methyl-5-nitropyridine-2-carbaldehyde

There total 7 articles about 6-Methyl-5-nitropyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-nitro-2,6-lutidine (15513-52-7,767567-84-0) → 6-methyl-5-nitropyridine-2-carbaldehyde (25033-74-3)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

N-(6-methyl-5-nitro-pyridin-2-ylmethylene)-N'-(4-phenyl-thiazol-2-yl)-hydrazine → 6-methyl-5-nitropyridine-2-carbaldehyde (25033-74-3) + 2-hydrazino-4-phenylthiazole (34176-52-8)

Guidance literature:

With oxonium; In N,N-dimethyl-formamide; at 30 ℃; pH=2.25; Further Variations:; pH-values; Kinetics;

DOI:10.1002/jccs.200100159

Reference yield:

N-(6-methyl-5-nitro-pyridin-2-ylmethylene)-N'-(4-p-tolyl-thiazol-2-yl)-hydrazine → 6-methyl-5-nitropyridine-2-carbaldehyde (25033-74-3) + 2-hydrazino-4-(4'-tolyl)thiazole (4872-78-0)

Guidance literature:

With oxonium; In N,N-dimethyl-formamide; at 30 ℃; pH=2.25; Further Variations:; pH-values; Kinetics;

DOI:10.1002/jccs.200100159

upstream raw materials:

3-nitro-2,6-lutidine

Downstream raw materials:

1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(hydroxymethyl)-2-methylpyridin-3-yl)urea

1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea

phenyl 6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-ylcarbamate

(6-methyl-5-nitropyridin-2-yl)methanol

Refernces

• 1、 -. "Therapeutically Active Thiazolo-Pyrimidine Derivatives". Paragraph 0259. . Retrieved 2014/10/29.
• 2、 -. "Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands". Paragraph 1047. . Retrieved 2013/03/26.