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4-(4-Methylphenyl)-2(3H)-thiazolone hydrazone is a chemical compound with the molecular formula C10H10N2S. It is a derivative of 2(3H)-thiazolone, featuring a 4-methylphenyl group attached to the 4-position of the thiazolone ring. 4-(4-METHYLPHENYL)-2(3H)-THIAZOLONE HYDRAZONE is known for its potential applications in the synthesis of various heterocyclic compounds and pharmaceuticals, particularly those with biological activity. It is an important intermediate in the preparation of certain drugs and agrochemicals, highlighting its significance in the field of organic chemistry and medicinal chemistry.

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  • 4872-78-0 Structure
  • Basic information

    1. Product Name: 4-(4-METHYLPHENYL)-2(3H)-THIAZOLONE HYDRAZONE
    2. Synonyms: 4-(4-METHYLPHENYL)-2(3H)-THIAZOLONE HYDRAZONE
    3. CAS NO:4872-78-0
    4. Molecular Formula: C10H11N3S
    5. Molecular Weight: 205.28
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4872-78-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-METHYLPHENYL)-2(3H)-THIAZOLONE HYDRAZONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-METHYLPHENYL)-2(3H)-THIAZOLONE HYDRAZONE(4872-78-0)
    11. EPA Substance Registry System: 4-(4-METHYLPHENYL)-2(3H)-THIAZOLONE HYDRAZONE(4872-78-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4872-78-0(Hazardous Substances Data)

4872-78-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4872-78-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,7 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4872-78:
(6*4)+(5*8)+(4*7)+(3*2)+(2*7)+(1*8)=120
120 % 10 = 0
So 4872-78-0 is a valid CAS Registry Number.

4872-78-0Relevant articles and documents

Novel thiazole–pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction

You, Hongwen,Su, Xinyou,Su, Guoying

, (2020/08/27)

A facile synthesis of a group of novel thiazole–pyrazolone hybrids and their investigation for angiotensin-converting enzyme (ACE) inhibition are reported in this study. These compounds were synthesized using a well-known approach, based on the condensation of ethyl acetoacetate with thiazolylhydrazines, and characterized by various spectroscopic and analytical techniques. The entire set of compounds displayed a moderate-to-excellent inhibitory activity against ACE. In particular, compound 4i was found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Compound 4i improved the cardiac function and prevented cardiac injury induced by ISO in Sprague Dawley rats. The levels of oxidative stress and proinflammatory cytokines were also restored to near normal by 4i as compared with the ISO group. In the Western blot analysis, compound 4i prevented mitochondrial apoptosis after MI by downregulating the expression of cleaved caspase-3 and Bax, with the upregulation of Bcl-2, as compared with the ISO group.

2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by C-H coupling and biological evaluation

Lohrey, Lilia,Uehara, Takahiro N.,Tani, Satoshi,Yamaguchi, Junichiro,Humpf, Hans-Ulrich,Itami, Kenichiro

supporting information, p. 3387 - 3394 (2014/06/09)

Life-threatening infections caused by bacteria that have developed resistance to common antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a serious problem in hospitals and other areas all over the world. Thus, the development of an effective class of antibiotics against these bacteria is an urgent subject. Herein, we report a step-economical and diversity-oriented synthesis of a series of 2-arylidenehydrazinyl-4- arylthiazole and 2-arylidenehydrazinyl-5-arylthiazole analogues that utilizes C-H coupling methodologies. A library of 54 new congeners were synthesized and tested for their biological potential. Moreover, new knowledge regarding the structure-activity relationships (SARs) of these heterobiaryl compounds was collected. Copyright

Spectrophotometric and polarographic studies on the kinetics of hydrolysis of N-(6-methyl-5-nitropyridin-2-yl methylidene)-N′-(substituted thiazol-2-yl)hydrazines

El-Nady, Abobakr M.

, p. 1081 - 1086 (2007/10/03)

The kinetics of the hydrolysis of hydrazpne derived from nitropyridine 2-carboxaldehyde and 2-hydrazino-4-substituted thiazoles la-e in 10% (v/v) DMF-buffer mixture has been investigated by applying two independent and different techniques viz UV-spectrop

MAOI activity of some novel series of substituted thiazol-2-yl-hydrazines

Mazzone,Pignatello,Panico,Mazzone,Puglisi,Pennisi,Raciti,Mazzone,Matera

, p. 902 - 910 (2007/10/02)

Three series of 2-thiazolylhydrazines were synthetized and evaluated for their MAO inhibitory (MAOI) activity, both by in vivo tests, to assay their influence on several MAOI activity-related parameters (the variation on blood pressure induced by tyramine

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