8-Ethoxyquinoline

Base Information

• Chemical Name: 8-Ethoxyquinoline
• CAS No.: 1555-94-8
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933499090
• European Community (EC) Number: 216-308-5
• NSC Number: 646914
• UNII: 16687500TQ
• DSSTox Substance ID: DTXSID80165909
• Nikkaji Number: J206.780C
• Wikidata: Q27251783
• ChEMBL ID: CHEMBL1971171
• Mol file: 1555-94-8.mol

Synonyms:8-Ethoxyquinoline;1555-94-8;Quinoline, 8-ethoxy-;CCRIS 7822;EINECS 216-308-5;NSC646914;UNII-16687500TQ;16687500TQ;Quinoline,8-ethoxy-;8-ETHOXY QUINOLINE;SCHEMBL1101347;CHEMBL1971171;DTXSID80165909;BAA55594;MFCD00039728;STL253602;AKOS002291251;NSC-646914;SB67438;NCI60_016213;LS-188242;CS-0337071;FT-0633662;A809658;Q27251783

Chemical Property of 8-Ethoxyquinoline

Chemical Property:

• Appearance/Colour: colorless or yellow liquid
• Vapor Pressure: 0.00286mmHg at 25°C
• Melting Point: 285 °C
• Refractive Index: 1.595
• Boiling Point: 294.4 °C at 760 mmHg
• PKA: 3.40±0.17(Predicted)
• Flash Point: 108 °C
• PSA: 22.12000
• Density: 1.101 g/cm³
• LogP: 2.63350
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

8-ETHOXY QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC2=C1N=CC=C2

Technology Process of 8-Ethoxyquinoline

There total 10 articles about 8-Ethoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

8-quinolinol (148-24-3,24804-14-6) + ethyl bromide (74-96-4) → 8-ethoxyquinoline (1555-94-8)

Guidance literature:

With potassium hydroxide; Aliquat; at 60 ℃; for 1h;

Reference yield: 69.0%

8-ethoxy-1,2,3,4-tetrahydroquinoline (103502-43-8) → 8-ethoxyquinoline (1555-94-8)

Guidance literature:

With iron oxide surrounded by nitrogen doped graphene shell immobilized on carbon support; In n-heptane; at 100 ℃; for 12h; under 11251.1 Torr; Autoclave;

DOI:10.1021/jacs.5b05674

Reference yield: 69.0%

Propargylic aldehyde (624-67-9) + ortho-phenitidine (94-70-2) → 8-ethoxyquinoline (1555-94-8)

Guidance literature:

With trifluorormethanesulfonic acid; silver trifluoromethanesulfonate; In toluene; at 80 ℃; for 4h;

DOI:10.1002/asia.201402742

upstream raw materials:

8-quinolinol

ethyl bromide

ethyl ester of p-toluenesulfonic acid

glycerol

Downstream raw materials:

8-ethoxy-1-benzyl-quinolinium; chloride

8-ethoxy-1-(toluene-4-sulfonyl)-quinolinium; chloride

8-ethoxy-1-(toluene-2-sulfonyl)-quinolinium; chloride

8-ethoxy-5-nitroquinoline