8-Ethoxy-5-nitroquinoline

Base Information

• Chemical Name: 8-Ethoxy-5-nitroquinoline
• CAS No.: 19746-57-7
• Molecular Formula: C11H10N2O3
• Molecular Weight: 218.212
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID90429443
• Wikidata: Q82242476
• Mol file: 19746-57-7.mol

Synonyms:8-ethoxy-5-nitroquinoline;19746-57-7;Quinoline, 8-ethoxy-5-nitro-;DTXSID90429443;MFCD00777819;AKOS015838842;BS-21904;CS-0151463;D94586;A880037

Chemical Property of 8-Ethoxy-5-nitroquinoline

Chemical Property:

• Melting Point: 127-128 °C
• Boiling Point: 390.1±27.0 °C(Predicted)
• PKA: 1.23±0.29(Predicted)
• PSA: 67.94000
• Density: 1.290±0.06 g/cm3(Predicted)
• LogP: 3.06490
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 218.06914219
• Heavy Atom Count: 16
• Complexity: 254

Purity/Quality:

97% ^*data from raw suppliers

8-Ethoxy-5-nitroquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=C2C(=C(C=C1)[N+](=O)[O-])C=CC=N2

Technology Process of 8-Ethoxy-5-nitroquinoline

There total 8 articles about 8-Ethoxy-5-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl bromide (74-96-4) + nitroxoline (4008-48-4) → 8-ethoxy-5-nitroquinoline (19746-57-7)

Guidance literature:

nitroxoline; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

ethyl bromide; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1080/14756366.2020.1780228

Reference yield:

nitroxoline (4008-48-4) → 8-ethoxy-5-nitroquinoline (19746-57-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 24h;

DOI:10.1007/s12272-013-0006-9

Reference yield:

8-ethoxyquinoline (1555-94-8) → 8-ethoxy-5-nitroquinoline (19746-57-7)

Guidance literature:

With nitric acid; at 0 ℃; dann Erhitzen auf dem Wasserbad;

upstream raw materials:

8-ethoxyquinoline

ethyl iodide

nitric acid

8-quinolinol

Downstream raw materials:

8-ethoxy-quinolin-5-ylamine

nitroxoline