cis-2-(3,4-Dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene

Base Information

Chemical Name:cis-2-(3,4-Dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene
CAS No.:88114-56-1
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:
DSSTox Substance ID:DTXSID501007939
Mol file:88114-56-1.mol

Synonyms:CIS 19;CIS-19;cis-2-(3,4-dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene

Suppliers and Price of cis-2-(3,4-Dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CIS-19 95.00%
5MG
$ 498.62

Total 0 raw suppliers

Chemical Property of cis-2-(3,4-Dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Vapor Pressure:1.7E-12mmHg at 25°C
Boiling Point:558.2°C at 760 mmHg
Flash Point:291.4°C
PSA：57.23000
Density:1.16g/cm³
LogP:4.99480
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:413.22022309
Heavy Atom Count:30
Complexity:544

Purity/Quality:: CIS-19 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)OC1=C(C=C2C(C(CCC2=C1)C3=CC(=C(C=C3)OC)OC)N(C)C=O)OC
Isomeric SMILES:CC(C)OC1=C(C=C2[C@@H]([C@@H](CCC2=C1)C3=CC(=C(C=C3)OC)OC)N(C)C=O)OC

Technology Process of cis-2-(3,4-Dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene

There total 9 articles about cis-2-(3,4-Dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methylformamido)-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.1%

: 75-87-6
chloral

: 88114-53-8,113964-95-7
cis-2-(3,4-dimethylphenyl)-6-isopropoxy-7-methoxy-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

: 88114-56-1,113964-93-5
cis-2-(3,4-dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methyl-formamido)-1,2,3,4-tetrahydronaphthalene

Guidance literature:: DOI:10.1248/cpb.31.2963

Reference yield:

: 88114-45-8
3'-isopropoxy-3,4,4'-trimethoxychalcone

: 88114-56-1,113964-93-5
cis-2-(3,4-dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methyl-formamido)-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 7 steps

1: 75.5 percent / acetic acid / 2-ethoxy-ethanol

2: 95.9 percent / sodium hydroxide, H₂O / ethanol / 7.5 h / Heating

3: H₂ / 10percent palladium-charcoal

4: 71 percent / phosphorus oxychloride / CHCl₃ / 2.5 h / 80 °C

5: titanium tetrachloride / CHCl₃ / -5 - 0 °C

6: sodium borohydride

7: 88.1 percent

With sodium hydroxide; sodium tetrahydroborate; water; hydrogen; titanium tetrachloride; acetic acid; trichlorophosphate; palladium on activated charcoal; In 2-ethoxy-ethanol; ethanol; chloroform;
DOI:10.1248/cpb.31.2963

Reference yield:

: 88114-47-0
2-(3,4-dimethoxyphenyl)-4-(3-isopropoxy-4-methoxyphenyl)-4-oxobutyric acid

: 88114-56-1,113964-93-5
cis-2-(3,4-dimethoxyphenyl)-6-isopropoxy-7-methoxy-1-(N-methyl-formamido)-1,2,3,4-tetrahydronaphthalene

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent palladium-charcoal

2: 71 percent / phosphorus oxychloride / CHCl₃ / 2.5 h / 80 °C

3: titanium tetrachloride / CHCl₃ / -5 - 0 °C

4: sodium borohydride

5: 88.1 percent

With sodium tetrahydroborate; hydrogen; titanium tetrachloride; trichlorophosphate; palladium on activated charcoal; In chloroform;
DOI:10.1248/cpb.31.2963