3-(7-Methoxy-1,3-benzodioxol-5-yl)phenol

Base Information

Chemical Name:3-(7-Methoxy-1,3-benzodioxol-5-yl)phenol
CAS No.:136051-64-4
Molecular Formula:C₁₄H₁₂O₄
Molecular Weight:244.247
Hs Code.:
DSSTox Substance ID:DTXSID10159639
Nikkaji Number:J584.143G
Wikidata:Q83028005
Mol file:136051-64-4.mol

Synonyms:3'-HMMDB;3'-hydroxy-5-methoxy-3,4-methylenedioxybiphenyl

Suppliers and Price of 3-(7-Methoxy-1,3-benzodioxol-5-yl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 3-(7-Methoxy-1,3-benzodioxol-5-yl)phenol

Chemical Property:

Boiling Point:416.7°Cat760mmHg
Flash Point:205.8°C
PSA：47.92000
Density:1.296g/cm³
LogP:2.79650
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:244.07355886
Heavy Atom Count:18
Complexity:283

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC2=C1OCO2)C3=CC(=CC=C3)O

Technology Process of 3-(7-Methoxy-1,3-benzodioxol-5-yl)phenol

There total 3 articles about 3-(7-Methoxy-1,3-benzodioxol-5-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 87199-18-6
3-hydroxyphenylboronic acid

: 91511-83-0
5-bromo-7-methoxy-1,3-benzodioxol

: 136051-64-4
3'-hydroxy-5-methoxy-3,4-methylenedioxybiphenyl

Guidance literature:: With palladium 10% on activated carbon; potassium hydroxide; at 150 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;
DOI:10.1021/jo500675a

Reference yield:

: 5034-74-2
5-bromo-3-methoxysalicylaldehyde

: 136051-64-4
3'-hydroxy-5-methoxy-3,4-methylenedioxybiphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Heating; Inert atmosphere

3: palladium 10% on activated carbon; potassium hydroxide / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

With palladium 10% on activated carbon; dihydrogen peroxide; potassium carbonate; potassium hydroxide; sodium hydroxide; In water; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo500675a

Reference yield:

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 136051-64-4
3'-hydroxy-5-methoxy-3,4-methylenedioxybiphenyl

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate; bromine / acetic acid / 0.5 h / 20 °C / Inert atmosphere

2: sodium hydroxide; dihydrogen peroxide / water / 0.5 h / 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Heating; Inert atmosphere

4: palladium 10% on activated carbon; potassium hydroxide / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

With palladium 10% on activated carbon; dihydrogen peroxide; bromine; sodium acetate; potassium carbonate; potassium hydroxide; sodium hydroxide; In water; acetic acid; N,N-dimethyl-formamide; 4: |Suzuki-Miyaura Coupling;
DOI:10.1021/jo500675a