succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone

Base Information

Chemical Name:succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone
CAS No.:65144-33-4
Molecular Formula:C₂₁H₃₃ClN₄O₇
Molecular Weight:488.969
Hs Code.:
Mol file:65144-33-4.mol

Synonyms:L-Prolinamide,N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-[3-chloro-1-(1-methylethyl)-2-oxopropyl]-,(S)-

Suppliers and Price of succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone

Chemical Property:

Vapor Pressure:1.39E-26mmHg at 25°C
Boiling Point:778.8°C at 760 mmHg
Flash Point:424.8°C
PSA：161.98000
Density:1.275g/cm³
LogP:0.91090

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone

There total 12 articles about succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21027-01-0
N-benzyloxycarbonyl-L-alanyl-L-proline

: 65144-33-4
N-3-carboxypropanoyl-alanyl-alanyl-prolyl-valyl-chloromethylketone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogene / Pd-C / aq. NaOH

2: dioxane / 24 h

3: 72 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / -15 - 20 °C

4: 6.2N HCl / dioxane / 1 h

5: acetonitrile / 18 h

With N-ethylmorpholine;; hydrogenchloride; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; sodium hydroxide; acetonitrile;

Reference yield:

: 51370-20-8
valyl-chloromethylketone

: 65144-33-4
N-3-carboxypropanoyl-alanyl-alanyl-prolyl-valyl-chloromethylketone

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / -15 - 20 °C

2: 6.2N HCl / dioxane / 1 h

3: acetonitrile / 18 h

With N-ethylmorpholine;; hydrogenchloride; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 90105-41-2
(S)-1-chloro-3-(benzyloxycarbonylamino)-4-methyl-2-pentanone

: 65144-33-4
N-3-carboxypropanoyl-alanyl-alanyl-prolyl-valyl-chloromethylketone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 5.6N HBr/AcOH, 2.) N-ethyl-morpholine / 1.) 5min, 2.) DMF

2: 72 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / -15 - 20 °C

3: 6.2N HCl / dioxane / 1 h

4: acetonitrile / 18 h

With N-ethylmorpholine;; hydrogenchloride; hydrogen bromide; acetic acid; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; acetonitrile;