Chemical Property of Ricinine
Chemical Property:
- Vapor Pressure:1.07E-05mmHg at 25°C
- Melting Point:200-201 °C.
- Refractive Index:1.6000 (estimate)
- Boiling Point:370.9 °C at 760 mmHg
- PKA:-4.93±0.62(Predicted)
- Flash Point:178.1 °C
- PSA：55.02000
- Density:1.23 g/cm3
- LogP:0.26558
- Storage Temp.:?20°C
- Water Solubility.:2.7g/L(10 oC)
- XLogP3:0
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:1
- Exact Mass:164.058577502
- Heavy Atom Count:12
- Complexity:319
- Purity/Quality:
-
HPLC≥98% *data from raw suppliers
Ricinine *data from reagent suppliers
Safty Information:
- Pictogram(s):
A poison by ingestion.
- Hazard Codes:T,Xn,F
- Statements:
25-36-20/21/22-11
- Safety Statements:
45-36/37-16
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN1C=CC(=C(C1=O)C#N)OC
-
Description
First isolated by Tuson from the seeds of Ricinus communis (castor-oil seed),
the alkaloid was subsequently examined by Soave, Schultze and Evans. The base
crystallizes from H20 in colourless prisms or leaflets and sublimes at 170-lS0°C/
20 mm. It is soluble in hot H20 or CHCI3, only sparingly so in EtOH and insoluble in petroleum ether, is neutral in reaction, optically inactive and forms no
normal salts although the mercurichloride, m.p. 204°C has been prepared. The
alkaloid reduces KMn04 and may be hydrolyzed by alkalies to MeOH and
ricininic acid which forms brilliant, slender needles, m.p. 296-8°C (dec.). The
structure of ricinine has been confirmed by synthesis from 4-chloroquinoline.
Other syntheses have also been achieved. The base is not particularly toxic and
the poisonous character of castor-oil seeds has been shown to be due to a more
complex substance, ricin, the toxicity of which may be destroyed by heating.
-
Uses
An alkaloid extract from the seeds of the castor-oil plant (Ricinus communalis). It is a central nervous system stimulant that could potentially be a cognition-enhancing agent used for the treatment of human amnesias. It also has bactericidal effects on t Ricinine is an alkaloid extract from the seeds of the castor-oil plant (Ricinus communalis). Ricinine is a central nervous system stimulant that could potentially be a cognition-enhancing agent used for the treatment of human amnesias. Ricinine also has bactericidal effects on three pests and heptaprotective activity.
