N-Ethylbenzimidazole

Base Information

• Chemical Name: N-Ethylbenzimidazole
• CAS No.: 7035-68-9
• Molecular Formula: C9H10N2
• Molecular Weight: 146.192
• Hs Code.: 2933990090
• Mol file: 7035-68-9.mol

Synonyms:1-Ethyl-1H-benzoimidazole

Chemical Property of N-Ethylbenzimidazole

Chemical Property:

• Vapor Pressure: 0.00828mmHg at 25°C
• Boiling Point: 267.2°C at 760 mmHg
• PKA: 5.50±0.10(Predicted)
• Flash Point: 115.4°C
• PSA: 17.82000
• Density: 1.08g/cm³
• LogP: 2.05620

Purity/Quality:

98%min ^*data from raw suppliers

1-Ethyl-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Ethylbenzimidazole

There total 28 articles about N-Ethylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

carbon dioxide (124-38-9,18923-20-1) + N-Ethyl-2-nitroaniline (10112-15-9) → 1-Ethylbenzimidazole (7035-68-9)

Guidance literature:

With palladium 10% on activated carbon; phenylsilane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In acetonitrile; at 70 ℃; for 15h; under 7500.75 Torr;

DOI:10.1016/j.tetlet.2021.152940

Reference yield: 93.0%

benzoimidazole (51-17-2,79351-71-6) + ethyl bromide (74-96-4) → 1-Ethylbenzimidazole (7035-68-9)

Guidance literature:

With potassium hydroxide; PEG-400-Et₂; In water; benzene; at 30 ℃; for 3h;

DOI:10.1246/bcsj.56.280

Reference yield: 93.0%

formic acid (64-18-6) + N-Ethyl-2-nitroaniline (10112-15-9) → 1-Ethylbenzimidazole (7035-68-9)

Guidance literature:

With iron; ammonium chloride; In isopropyl alcohol; at 80 ℃; for 2h;

DOI:10.1055/s-0030-1259007

upstream raw materials:

N-ethyl-o-phenylenediamine; dihydrochloride

1-ethyl-3-methyl-1H-benzo[d]imidazol-3-ium iodide

1,3-diethyl-1H-benzo[d]imidazol-3-ium iodide

1-ethyl-3-benzylbenzimidazolium iodide

Downstream raw materials:

1-ethyl-1H-benzo[d]imidazole-2-thiol

1-ethyl-N-phenyl-1H-benzo[d]imidazol-2-amine

6-Ethyl-benzimidazo<1,2-b>chinazolin-12(6H)-on

1-ethyl-1H-benzimidazole-2-sulfonic acid

Refernces

• 1、 Hernández Carrillo, Rubí,Suarez-Guevara, Jullieth,Torres-González, Luis Carlos,Gómez-Romero, Pedro,Sánchez, Eduardo M.. "Incorporation of benzimidazolium ionic liquid in proton exchange membranes ABPBI-H3PO4". . p. 115 - 120. Retrieved 2013.
• 2、 Liu, Qing-Xiang,Shi, Meng-Chao,Wang, Zhi-Qiang,Liu, Shu-Wen,Ge, Shu-Sheng,Zang, Yan,Wang, Xiu-Guang,Guo, Jian-Hua. "1D coordination polymers of silver(I) and copper(II) based on bis(N-heterocyclic carbene) ligands: Synthesis and structural studies". . p. 2121 - 2126. Retrieved 2010.
• 3、 Li, Yibiao,Liu, Qiang,Shao, Zhihui,Yuan, Shanshan. "Using Methanol as a Formaldehyde Surrogate for Sustainable Synthesis of N-Heterocycles via Manganese-Catalyzed Dehydrogenative Cyclization". supporting information. . Retrieved 2022/02/23.
• 4、 Rissanen, Kari,Siepmann, Marcel,Taipale, Essi,Truong, Khai-Nghi. "Iodine(I) and Silver(I) Complexes of Benzoimidazole and Pyridylcarbazole Derivatives". supporting information. p. 17412 - 17419. Retrieved 2021/10/19.