4-Fluoro-N-prop-2-ynylbenzamide

Base Information

Chemical Name:4-Fluoro-N-prop-2-ynylbenzamide
CAS No.:82225-36-3
Molecular Formula:C10H8FNO
Molecular Weight:177.178
Hs Code.:
DSSTox Substance ID:DTXSID50231640
Nikkaji Number:J3.125.218K
Wikidata:Q83112576

Synonyms:4-Fluoro-N-prop-2-ynylbenzamide;82225-36-3;Benzamide, 4-fluoro-N-prop-2-ynyl-;N-Propargyl-4-fluorobenzamide;SCHEMBL2605517;DTXSID50231640;AKOS008956308;N-(prop-2-yn-1-yl)-4-fluorobenzamide;Z52403932

Suppliers and Price of 4-Fluoro-N-prop-2-ynylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-Fluoro-N-prop-2-ynylbenzamide

Chemical Property:

Vapor Pressure:0.000477mmHg at 25°C
Boiling Point:314.1°Cat760mmHg
Flash Point:143.8°C
Density:1.175g/cm³
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:177.058992041
Heavy Atom Count:13
Complexity:222

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CCNC(=O)C1=CC=C(C=C1)F

Technology Process of 4-Fluoro-N-prop-2-ynylbenzamide

There total 6 articles about 4-Fluoro-N-prop-2-ynylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 403-43-0
4-fluorobenzoyl chloride

: 2450-71-7
Propargylamine

: 82225-36-3
4-fluoro-N-(prop-2-yn-1-yl)benzamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 3.25h; Inert atmosphere;
DOI:10.1002/adsc.201800246

Reference yield: 87.0%

: 456-22-4
4-Fluorobenzoic acid

: 2450-71-7
Propargylamine

: 82225-36-3
4-fluoro-N-(prop-2-yn-1-yl)benzamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;
DOI:10.1021/acs.orglett.9b02884

Reference yield: 67.22%

: 82225-36-3
4-fluoro-N-(prop-2-yn-1-yl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;