2-Methoxy-2,8-diazaspiro(4,5)decane-1,3-dione hydrochloride

Base Information

• Chemical Name: 2-Methoxy-2,8-diazaspiro(4,5)decane-1,3-dione hydrochloride
• CAS No.: 117281-08-0
• Molecular Formula: C9H14 N2 O3 . Cl H
• Molecular Weight: 234.68
• DSSTox Substance ID: DTXSID70151755

Synonyms:2-Methoxy-2,8-diazaspiro(4,5)decane-1,3-dione hydrochloride;2,8-Diazaspiro(4,5)decane-1,3-dione, 2-methoxy-, monohydrochloride;117281-08-0;2-Methoxy-2,8-diazaspiro(4,5)decane-1,3-dione monohydrochloride;2-methoxy-2,8-diazaspiro[4,5]decane-1,3-dione hydrochloride;C9H14N2O3.ClH;SCHEMBL10563363;DTXSID70151755;AQGQDABWRORTCI-UHFFFAOYSA-N;LS-59981;2-methoxy-2,8-diazaspiro[4,5]decane-1,3-dione.hydrochloride;2-Methoxy-2,8-diazaspiro[4,5]decane-1,3-dionehydrochloride

Chemical Property of 2-Methoxy-2,8-diazaspiro(4,5)decane-1,3-dione hydrochloride

Chemical Property:

• Vapor Pressure: 0.000641mmHg at 25°C
• Boiling Point: 309.4°Cat760mmHg
• Flash Point: 140.9°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 234.0771200
• Heavy Atom Count: 15
• Complexity: 271

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CON1C(=O)CC2(C1=O)CCNCC2.Cl

Technology Process of 2-Methoxy-2,8-diazaspiro(4,5)decane-1,3-dione hydrochloride

There total 3 articles about 2-Methoxy-2,8-diazaspiro(4,5)decane-1,3-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-methoxy-8-(phenylmethyl)-2,8-diazaspiro<4.5>decane-1,3-dione hydrochloride (117280-95-2) → 2-methoxy-2,8-diazaspiro<4.5>decane-1,3-dione hydrochloride (117281-08-0)

Guidance literature:

With hydrogen; palladium; In water; for 10h; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.40.1177

Reference yield:

8-benzyloxycarbonyl-2-methoxy-2,8-diazaspiro[4.5]decane-1,3-dione → 2-methoxy-2,8-diazaspiro<4.5>decane-1,3-dione hydrochloride (117281-08-0)

Guidance literature:

palladium; In hydrogenchloride; methanol;

Reference yield:

4-Nitrophenyl chloroformate (7693-46-1) + 2-bromoethanol (540-51-2) → 2-methoxy-2,8-diazaspiro<4.5>decane-1,3-dione hydrochloride (117281-08-0)

Guidance literature:

With pyridine; In N-methyl-acetamide;

upstream raw materials:

2-methoxy-8-(phenylmethyl)-2,8-diazaspiro<4.5>decane-1,3-dione hydrochloride

4-Nitrophenyl chloroformate

2-bromoethanol

Downstream raw materials:

8-[1,4-Dihydro-2,6-dimethyl-5methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carbonyl]-2-methoxy-2,8-diazaspiro[4,5]decane-1,3-dione

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