TRIMETHYLSILYL 3-METHYLBUTYRATE

Base Information

• Chemical Name: TRIMETHYLSILYL 3-METHYLBUTYRATE
• CAS No.: 55557-13-6
• Molecular Formula: C8H18 O2 Si
• Molecular Weight: 174.315
• Mol file: 55557-13-6.mol

Synonyms:TRIMETHYLSILYL 3-METHYLBUTYRATE

Chemical Property of TRIMETHYLSILYL 3-METHYLBUTYRATE

Chemical Property:

• Vapor Pressure: 2.7mmHg at 25°C
• Boiling Point: 157.8°Cat760mmHg
• Flash Point: 41.1°C
• PSA: 26.30000
• Density: 0.87g/cm³
• LogP: 2.41060
• Storage Temp.: 0-6°C

Purity/Quality:

98%Min ^*data from raw suppliers

TRIMETHYLSILYL 3-METHYLBUTYRATE 95.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRIMETHYLSILYL 3-METHYLBUTYRATE

There total 5 articles about TRIMETHYLSILYL 3-METHYLBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylbutyric acid (503-74-2) + chloro-trimethyl-silane (75-77-4) → 3-methylbutyric acid trimethylsilyl ester (55557-13-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(01)91624-7

Reference yield:

3-methylbutyric acid (503-74-2) + trimethylsilyl 2-methylprop-2-ene-1-sulfinate (723336-86-5) → 3-methylbutyric acid trimethylsilyl ester (55557-13-6)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ol401053y

Reference yield:

(-)-atractyloside potassium salt (17754-44-8,102130-43-8) + 1-(Trimethylsilyl)imidazole (18156-74-6) → 3-methylbutyric acid trimethylsilyl ester (55557-13-6) + C37H68O7Si4

Guidance literature:

(-)-atractyloside potassium salt; for 2h; Heating; Acidic conditions;

1-(Trimethylsilyl)imidazole; With pyridine; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.3390/molecules18022018

upstream raw materials:

3-methylbutyric acid

chloro-trimethyl-silane

(-)-atractyloside potassium salt

1-(Trimethylsilyl)imidazole

Downstream raw materials:

3-methyl-2'-nitrobutananilide

1-methyl-3-phenylpropyl 3-methylbutyrate

3-methylphenyl 3-methylbutyrate

3-methylbutanoic acid 3-phenylpropyl ester

Refernces

• 1、 Chen, Liang-Yu,Hu, Anren,Chang, Chih-Jui. "The degradation mechanism of toxic atractyloside in herbal medicines by decoction". . p. 2018 - 2028. Retrieved 2013/04/10.
• 2、 Miyashita, Mitsutomo,Shiina, Isamu,Mukaiyama, Teruaki. "An Effective Method for Acylation of Weakly Nucleophilic Anilines with Silyl Carboxylates via Mixed Anhydrides". . p. 210 - 215. Retrieved 2007/10/02.