2,4-Dimethoxy-1-nitrobenzene

Base Information

• Chemical Name: 2,4-Dimethoxy-1-nitrobenzene
• CAS No.: 4920-84-7
• Molecular Formula: C8H9NO4
• Molecular Weight: 183.164
• Hs Code.: 29093090
• European Community (EC) Number: 225-551-6
• NSC Number: 62004
• UNII: VBX4VSP74U
• DSSTox Substance ID: DTXSID80197720
• Nikkaji Number: J154.682A
• Wikidata: Q63396049
• Mol file: 4920-84-7.mol

Synonyms:2,4-dimethoxy-1-nitrobenzene;4920-84-7;1,3-Dimethoxy-4-nitrobenzene;2,4-Dimethoxynitrobenzene;Benzene, 2,4-dimethoxy-1-nitro-;VBX4VSP74U;EINECS 225-551-6;NSC-62004;2,4-dimethoxy-1-nitro-benzene;NSC62004;UNII-VBX4VSP74U;2,4dimethoxy-nitrobenzene;2,4-dimethoxy-nitrobenzene;2.4-dimethoxy-nitrobenzene;SCHEMBL4142866;DTXSID80197720;1,3-Dimethoxy-4-nitrobenzene 97%;MFCD00024210;NSC 62004;1,3-Dimethoxy-4-nitrobenzene, 97%;AKOS015851775;AM62517;CS-W017061;PS-4904;AC-11251;A7367;D4382;FT-0635482;EN300-152809;CS-001/03839047;Q63396049

Chemical Property of 2,4-Dimethoxy-1-nitrobenzene

Chemical Property:

• Appearance/Colour: yellow crystals
• Vapor Pressure: 0.000695mmHg at 25°C
• Melting Point: 72-76 °C(lit.)
• Refractive Index: 1.53
• Boiling Point: 317.9 °C at 760 mmHg
• Flash Point: 156.7 °C
• PSA: 64.28000
• Density: 1.226 g/cm³
• LogP: 2.13520
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Toluene
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 183.05315777
• Heavy Atom Count: 13
• Complexity: 180

Purity/Quality:

99.9% ^*data from raw suppliers

2,4-Dimethoxy-1-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)[N+](=O)[O-])OC

Technology Process of 2,4-Dimethoxy-1-nitrobenzene

There total 40 articles about 2,4-Dimethoxy-1-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tetramethylorthosilicate (681-84-5) + 2,4-Difluoronitrobenzene (446-35-5) → 2,4-dimethoxynitrobenzene (4920-84-7)

Guidance literature:

With tetrabutyl ammonium fluoride; at 80 ℃; for 2h;

DOI:10.3184/030823410X12791804205820

Reference yield: 85.0%

2,4-Dimethoxyaniline (2735-04-8,161687-55-4) → 2,4-dimethoxynitrobenzene (4920-84-7)

Guidance literature:

With Oxone; potassium hydroxide; disodium hydrogenphosphate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; acetone; at 0 ℃; pH=7.5-8.5;

DOI:10.1016/S0040-4039(00)80531-6

Reference yield: 84.0%

2,4-dichloronitrobenzene (611-06-3) + sodium methylate (124-41-4) → 2,4-dimethoxynitrobenzene (4920-84-7)

Guidance literature:

In methanol; for 25h; Heating;

upstream raw materials:

2,4-dichloronitrobenzene

sodium methylate

1-chloro-3-methoxy-4-nitrobenzene

2,5-dinitro-anisole

Downstream raw materials:

1,3-dimethoxy-4,6-dinitrobenzene

1-bromo-2,4-dimethoxy-5-nitrobenzene

N-acetyl-6-chloro-2,4-dimethoxyaniline

2,4-Dimethoxyaniline