2-Ethoxyoxane

Base Information

• Chemical Name: 2-Ethoxyoxane
• CAS No.: 4819-83-4
• Molecular Formula: C7H14O2
• Molecular Weight: 130.187
• NSC Number: 84209
• UNII: HW9H85TH5V
• DSSTox Substance ID: DTXSID80292623
• Nikkaji Number: J121.655D
• Mol file: 4819-83-4.mol

Synonyms:2-Ethoxyoxane;2-Ethoxytetrahydropyran;4819-83-4;2H-Pyran, 2-ethoxytetrahydro-;2-Ethoxytetrahydro-2H-pyran;Tetrahydro-2-ethoxypyran;Pyran, 2-ethoxytetrahydro-;HW9H85TH5V;NSC-84209;UNII-HW9H85TH5V;NSC84209;ethoxy-tetrahydropyran;2-ethoxy-tetrahydro-pyran;SCHEMBL734135;2-Ethoxytetrahydro-2H-pyran #;DTXSID80292623;AKOS024429061

Chemical Property of 2-Ethoxyoxane

Chemical Property:

• Vapor Pressure: 3.62mmHg at 25°C
• Boiling Point: 157.1°Cat760mmHg
• Flash Point: 42.5°C
• Density: 0.93g/cm³
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 130.099379685
• Heavy Atom Count: 9
• Complexity: 73.3

Purity/Quality:

99%min ^*data from raw suppliers

2-ETHOXYTETRAHYDROPYRAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1CCCCO1

Technology Process of 2-Ethoxyoxane

There total 12 articles about 2-Ethoxyoxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-ethoxy-2,3-dihydro-4H-pyran (103-75-3) → 2-ethoxytetrahydropyran (4819-83-4)

Guidance literature:

With fac-[Mn(1,2-bis(di-isopropylphosphino)ethane)(CO)₃(CH₂CH₂CH₃)]; hydrogen; In diethyl ether; at 60 ℃; for 24h; under 37503.8 Torr;

DOI:10.1021/acscatal.9b03963

Reference yield: 98.0%

3,4-dihydro-2H-pyran (110-87-2) + ethanol (64-17-5) → 2-ethoxytetrahydropyran (4819-83-4)

Guidance literature:

With N_.N'-bis[3,5-bis(trifluoromethyl)phenyl]thiourea; at 20 ℃; for 24h;

DOI:10.1055/s-2007-965917

Reference yield: 95.0%

2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4) → 2-ethoxytetrahydropyran (4819-83-4)

Guidance literature:

With nickel; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1055/s-2001-12325

upstream raw materials:

3,4-dihydro-2H-pyran

ethanol

(Z)-3-Ethoxy-but-2-en-1-ol

methyl vinyl ketone

Downstream raw materials:

5-hydroxy-valeraldehyde-(2,4-dinitro-phenylhydrazone)

TETRAHYDROPYRANE

5-ethoxypentan-1-ol

ethyl ester of p-toluenesulfonic acid

Refernces

• 1、 Weber, Stefan,St?ger, Berthold,Veiros, Luis F.,Kirchner, Karl. "Rethinking Basic Concepts-Hydrogenation of Alkenes Catalyzed by Bench-Stable Alkyl Mn(I) Complexes". . p. 9715 - 9720. Retrieved 2019/10/14.
• 2、 Wang, Rui,Sun, Mingzhu,Jiang, Heng. "Solvent-free tetrahydropyranylation of alcohols catalyzed by amine methanesulfonates". experimental part. p. 61 - 67. Retrieved 2012/02/16.