2-(2-Pyridiniomethyl)isothiouronium dichloride

Base Information

• Chemical Name: 2-(2-Pyridiniomethyl)isothiouronium dichloride
• CAS No.: 1822-49-7
• Molecular Formula: C7H11Cl2N3S
• Molecular Weight: 240.156
• Mol file: 1822-49-7.mol

Synonyms:pyridin-2-ylmethyl carbamimidothioate dihydrochloride;EINECS 217-349-1;2-pyridin-2-ylmethyl-isothiourea-dihydrochloride;

Chemical Property of 2-(2-Pyridiniomethyl)isothiouronium dichloride

Chemical Property:

• PSA: 88.06000
• LogP: 3.61230

Purity/Quality:

99% ^*data from raw suppliers

Carbamimidothioicacid2-pyridinylmethylesterhydrochloride 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Pyridiniomethyl)isothiouronium dichloride

There total 3 articles about 2-(2-Pyridiniomethyl)isothiouronium dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-chloromethylpyridine hydrochloride (6959-47-3) + thiourea (17356-08-0) → 2-(2-pyridylmethyl)isothiourea dihydrochloride (1822-49-7)

Guidance literature:

In ethanol; for 1.5h; Heating;

DOI:10.1021/jm00384a004

Reference yield:

ethyl acetate-cyclohexane + 2-(4-methylpyrid-2-ylmethyl)isothiourea dihydrochloride (76732-82-6) + 1.3-chlorobromopropane (109-70-6) → 2-(2-pyridylmethyl)isothiourea dihydrochloride (1822-49-7) + (4-methylpyrid-2-yl)methyl 3-chloropropyl sulphide (76732-81-5)

Guidance literature:

Reference yield:

ethyl acetate-cyclohexane + 2-(5-methylpyrid-2-ylmethyl)isothiourea dihydrochloride (76732-85-9) + 1.3-chlorobromopropane (109-70-6) → 2-(2-pyridylmethyl)isothiourea dihydrochloride (1822-49-7) + (5-methylpyrid-2-yl)methyl 3-chloropropyl sulphide (76732-84-8)

Guidance literature:

upstream raw materials:

2-chloromethylpyridine hydrochloride

thiourea

2-(4-methylpyrid-2-ylmethyl)isothiourea dihydrochloride

1.3-chlorobromopropane

Downstream raw materials:

2-(2-pyridyl)tetrahydrothiophene

N-methyl-2-(2-pyridyl)tetrahydrothiophene-2-carbothioamide

2-Pyridin-2-yl-tetrahydro-thiophene-2-carbothioic acid phenylamide

2-Pyridin-2-yl-tetrahydro-thiophene-2-carbothioic acid benzylamide

Refernces

• 1、 Aloup, Jean-Claude,Bouchaudon, Jean,Farge, Daniel,James, Claude,Deregnaucourt, Jean,Hardy-Houis, Monique. "Synthesis and Antisecretory and Antiulcer Activities of Derivatives and Analogues of 2-(2-Pyridyl)tetrahydrothiophene-2-carbothioamide". . p. 24 - 29. Retrieved 2007/10/02.