N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide

Base Information

Chemical Name:N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide
CAS No.:117730-48-0
Molecular Formula:C₁₆H₁₄F₃NO₃
Molecular Weight:325.287
Hs Code.:
DSSTox Substance ID:DTXSID10922527
Nikkaji Number:J275.209C
Mol file:117730-48-0.mol

Synonyms:HTPH;N-(4-hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide

Suppliers and Price of N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide

Chemical Property:

Vapor Pressure:7.12E-10mmHg at 25°C
Boiling Point:480.9°Cat760mmHg
Flash Point:244.7°C
PSA：60.77000
Density:1.393g/cm³
LogP:3.69540
XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:325.09257779
Heavy Atom Count:23
Complexity:400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(F)(F)F)N(C1=CC=C(C=C1)O)C(=O)C2=CC=C(C=C2)O

Technology Process of N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide

There total 6 articles about N-(4-Hydroxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 117730-47-9
N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-methoxybenzamide

: 117730-48-0
N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxybenzamid

Guidance literature:: With boron tribromide; In dichloromethane; 1.) -60 deg C, 30 min, 2.) room temp., 4 h;
DOI:10.1002/ardp.19883210814

Reference yield:

: 14796-89-5
4-methoxy-N-(triphenylphosphoran-ylidene)-aniline

: 117730-48-0
N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxybenzamid

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / benzene / 12 h / Heating

2: 64 percent / LiAlH₄ / diethyl ether / 2 h / Heating

3: 68 percent / K₂CO₃; pyridine / toluene / 80 - 110 °C

4: 62 percent / BBr₃ / CH₂Cl₂ / 20 °C

With pyridine; lithium aluminium tetrahydride; boron tribromide; potassium carbonate; In diethyl ether; dichloromethane; toluene; benzene; 1: Staudinger reaction / 2: Reduction / 3: Acylation / 4: demethylation;
DOI:10.1016/S0968-0896(00)00075-4

Reference yield:

: 117730-46-8
N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline

: 117730-48-0
N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-hydroxybenzamid

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / K₂CO₃; pyridine / toluene / 80 - 110 °C

2: 62 percent / BBr₃ / CH₂Cl₂ / 20 °C

With pyridine; boron tribromide; potassium carbonate; In dichloromethane; toluene; 1: Acylation / 2: demethylation;
DOI:10.1016/S0968-0896(00)00075-4