N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline

Base Information

• Chemical Name: N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline
• CAS No.: 117730-46-8
• Molecular Formula: C₁₀H₁₂F₃NO
• Molecular Weight: 219.207
• Mol file: 117730-46-8.mol

Synonyms:N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline

Chemical Property of N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline

There total 4 articles about N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methoxy-N-[2,2,2-trifluoro-1-methylethylidene]aniline (117730-45-7) → N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline (117730-46-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Heating;

DOI:10.1002/ardp.19883210814

Reference yield:

4-methoxy-N-(triphenylphosphoran-ylidene)-aniline (14796-89-5) → N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline (117730-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / benzene / 12 h / Heating

2: 64 percent / LiAlH₄ / diethyl ether / 2 h / Heating

With lithium aluminium tetrahydride; In diethyl ether; benzene; 1: Staudinger reaction / 2: Reduction;

DOI:10.1016/S0968-0896(00)00075-4

Reference yield:

p-methoxy-phenylazide (2101-87-3) → N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline (117730-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 2 h / Heating

2: 92 percent / benzene / 12 h / Heating

3: 64 percent / LiAlH₄ / diethyl ether / 2 h / Heating

With lithium aluminium tetrahydride; In diethyl ether; benzene; 1: Substitution / 2: Staudinger reaction / 3: Reduction;

DOI:10.1016/S0968-0896(00)00075-4

upstream raw materials:

4-methoxy-N-[2,2,2-trifluoro-1-methylethylidene]aniline

4-methoxy-N-(triphenylphosphoran-ylidene)-aniline

p-methoxy-phenylazide

4-methoxy-aniline

Downstream raw materials:

N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-4-methoxy-2-methylbenzamid

N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-methoxybenzamid

N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-brom-4-methoxybenzamid

N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-methoxybenzamide

Refernces

• 1、 Stauffer, Shaun R.,Sun, Jun,Katzenellenbogen, Benita S.,Katzenellenbogen, John A.. "Acyclic amides as estrogen receptor ligands: Synthesis, binding, activity and receptor interaction". . p. 1293 - 1316. Retrieved 2007/10/03.