2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)

Base Information

• Chemical Name: 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)
• CAS No.: 19178-37-1
• Molecular Formula: C8H9ClN2O
• Molecular Weight: 184.625
• Hs Code.: 2924299090
• Mol file: 19178-37-1.mol

Synonyms:5-Chloranthranil-methylamid;2-amino-5-chloro-N-methyl-benzamide;2-Amino-5-chloro-N-methylbenzamid;Benzamide,2-amino-5-chloro-N-methyl;2-Amino-5-chlor-N-methyl-benzamid;5-Chlor-anthranilsaeure-methylamid;

Chemical Property of 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)

Chemical Property:

• Vapor Pressure: 0.000124mmHg at 25°C
• Boiling Point: 334.9°Cat760mmHg
• Flash Point: 156.4°C
• PSA: 58.61000
• Density: 1.281g/cm³
• LogP: 2.43780

Purity/Quality:

98% ^*data from raw suppliers

2-amino-5-chloro-N-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)

There total 4 articles about 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-chloroanthranilic acid (635-21-2) + methylamine (74-89-5) → 2-amino-5-chloro-N-methylbenzamide (19178-37-1)

Guidance literature:

5-chloroanthranilic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

methylamine; In tetrahydrofuran; for 3h;

DOI:10.1080/00397911.2010.520403

Reference yield: 89.0%

→ 2-amino-5-chloro-N-methylbenzamide (19178-37-1)

Guidance literature:

Reference yield: 58.0%

methylamine hydrochloride (593-51-1) + 5-chloroanthranilic acid (635-21-2) → 2-amino-5-chloro-N-methylbenzamide (19178-37-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1039/d0ob00866d

upstream raw materials:

5-Chloroisatoic anhydride

methylamine

5-chloroanthranilic acid

methylamine hydrochloride

Downstream raw materials:

5-chloro-2-[[2-[(1,3-dimethylpyrazol-4-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-N-methyl-benzamide

4-chloro-2-(methylaminomethyl)aniline

Refernces

• 1、 Mao, Ming-Zhen,Wang, Hai-Yang,Wang, Wei,Ning, Bin-Ke,Li, Yu-Xin,Xiong, Li-Xia,Li, Zheng-Ming. "Synthesis and biological evaluation of novel N-pyridylpyrazolecarboxamides containing benzothiazole". . p. 42 - 46. Retrieved 2016/12/24.
• 2、 -. "PYRIDINE COMPOUNDS". Page/Page column 197. . Retrieved 2010/01/12.