2,3-Dihydrobenzofuran-4-ol

Base Information

• Chemical Name: 2,3-Dihydrobenzofuran-4-ol
• CAS No.: 144822-82-2
• Molecular Formula: C8H8O2
• Molecular Weight: 136.15
• European Community (EC) Number: 874-699-3
• DSSTox Substance ID: DTXSID20459339
• Nikkaji Number: J1.683.095J
• Wikidata: Q82283085
• Mol file: 144822-82-2.mol

Synonyms:2,3-dihydrobenzofuran-4-ol;144822-82-2;2,3-dihydro-1-benzofuran-4-ol;4-Benzofuranol, 2,3-dihydro-;2,3-dihydro-4-hydroxybenzofuran;4-hydroxy-dihyrobenzofuran;SCHEMBL88337;2,3-Dihydro-4-benzofuranol;2,3-Dihydro-benzofuran-4-ol;DTXSID20459339;IMHHWOCMTWWBAQ-UHFFFAOYSA-N;2,3-dihydro-4-hydroxy-benzofuran;AKOS006291531;AB92791;AS-80373;CS-0136454;E81689;EN300-249371;A908210;F2147-8781;Z1198181637

Chemical Property of 2,3-Dihydrobenzofuran-4-ol

Chemical Property:

• Melting Point: 75 °C
• Boiling Point: 252 °C at 760 mmHg
• PKA: 9.89±0.20(Predicted)
• Flash Point: 118.7 °C
• PSA: 29.46000
• Density: 1.26 g/cm³
• LogP: 1.32710
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 136.052429494
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

97% ^*data from raw suppliers

2,3-DIHYDRO-1-BENZOFURAN-4-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC2=CC=CC(=C21)O

Technology Process of 2,3-Dihydrobenzofuran-4-ol

There total 12 articles about 2,3-Dihydrobenzofuran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

acetic acid 4-acetoxy-2,3-dihydro-benzofuran-3-yl ester (444711-08-4) → 4-hydroxy-2,3-dihydrobenzofuran (144822-82-2)

Guidance literature:

acetic acid 4-acetoxy-2,3-dihydro-benzofuran-3-yl ester; With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; under 155.144 Torr;

With sodium hydroxide;

DOI:10.1016/S0040-4039(02)00157-0

Reference yield: 67.0%

2-(2,6-dimethoxyphenyl)ethanol (14534-76-0) → 4-hydroxy-2,3-dihydrobenzofuran (144822-82-2)

Guidance literature:

With hydrogen bromide; In water; at 105 ℃; for 12h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 67.0%

C14H19BO3 → 4-hydroxy-2,3-dihydrobenzofuran (144822-82-2)

Guidance literature:

With water; 4-methylmorpholine N-oxide; In 1,4-dioxane; for 1h; Heating;

upstream raw materials:

4-hydroxybenzofuran

acetic acid 4-acetoxy-2,3-dihydro-benzofuran-3-yl ester

2,6-dihydroxylacetophenone

2,6-diacetoxyacetophenone

Downstream raw materials:

3-Benzyl-10-(4-hydroxy-2,3-dihydro-benzofuran-5-yl)-1,2,3,4,5,10,15,16-octahydro-7,17-dioxa-3-aza-cyclopenta[a]phenanthren-6-one

2-benzyl-1,2,3,4,8,9-hexahydro-11H-furo<3',2':7,8><1>benzopyrano<3,4-c>pyridin-11-one