BENZOYL-DL-VALINE

Base Information

• Chemical Name: BENZOYL-DL-VALINE
• CAS No.: 2901-80-6
• Molecular Formula: C12H15 N O3
• Molecular Weight: 221.256
• Hs Code.: 2924299090
• Mol file: 2901-80-6.mol

Synonyms:DL-Valine,N-benzoyl-; Valine, N-benzoyl-, DL- (6CI,7CI,8CI); DL-Benzoylvaline;DL-N-Benzoylvaline; N-Benzoyl-DL-valine; N-Benzoyl-DL-a-valine; NSC 334211

Chemical Property of BENZOYL-DL-VALINE

Chemical Property:

• Vapor Pressure: 5.98E-09mmHg at 25°C
• Melting Point: 132oC
• Boiling Point: 451.8°Cat760mmHg
• PKA: 3.79±0.10(Predicted)
• Flash Point: 227°C
• PSA: 66.40000
• Density: 1.157g/cm³
• LogP: 1.91650
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: almost transparency in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzoyl-dl-valine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOYL-DL-VALINE

There total 43 articles about BENZOYL-DL-VALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzoyl chloride (98-88-4) + D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → N-benzoyl-D,L-valine (2901-80-6)

Guidance literature:

With sodium hydroxide; In water;

Reference yield: 83.0%

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + benzoyl chloride (98-88-4) → N-benzoyl-L-valine (2901-80-6,80394-38-3,5699-79-6)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; at 0 - 20 ℃;

DOI:10.1016/j.tetasy.2010.03.002

Reference yield: 51.0%

D-Val-OH (640-68-6,25609-85-2,7004-03-7,921-10-8) + benzoyl chloride (98-88-4) → N-benzoyl-L-valine (2901-80-6,80394-38-3,5699-79-6)

Guidance literature:

D-Val-OH; benzoyl chloride; With sodium hydroxide; In water; for 3h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; at 0 ℃; for 0.5h; pH=1; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.03.140

upstream raw materials:

benzoyl chloride

D,L-valine

methanol

2-phenyl-4-iso-propyl-4H-oxazolin-5-one

Downstream raw materials:

N-benzoyl-D-valyl chloride

N-benzoyl-O-(N-benzoyl-valyl)-threonine

L-valine

(2R)-2-(benzoylamino)-3-methylbutyric acid

Refernces

• 1、 Chen, Jian,Zhu, Shaolin. "Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes". supporting information. p. 14089 - 14096. Retrieved 2021/09/13.
• 2、 Arfan, M.,Fatima, T.,Mannan, A.,Tahira, A.. "A Facile Approach to the Synthesis of Benzothiazoles from N-Protected Amino Acids". . p. 292 - 297. Retrieved 2020/04/21.