2-Methylpyrimidine

Base Information

• Chemical Name: 2-Methylpyrimidine
• CAS No.: 5053-43-0
• Molecular Formula: C5H6N2
• Molecular Weight: 94.116
• Mol file: 5053-43-0.mol

Synonyms:2-Methyl-1,3-diazine;

Chemical Property of 2-Methylpyrimidine

Chemical Property:

• Vapor Pressure: 17mmHg at 25°C
• Melting Point: -4°C
• Refractive Index: n20/D 1.4930
• Boiling Point: 122.1 °C at 760 mmHg
• PKA: 1.85±0.13(Predicted)
• Flash Point: 20.3 °C
• PSA: 25.78000
• Density: 1.021 g/cm³
• LogP: 0.78500

Purity/Quality:

99% ^*data from raw suppliers

2-Methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 10-36/37/38-41-37/38-22
• Safety Statements: 16-26-36/37/39-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Methylpyrimidine is used in preparation of pyrimidine derivative and related heterocycles as complement modulators for treatment of diseases.

Technology Process of 2-Methylpyrimidine

There total 24 articles about 2-Methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetamidine hydrochloride (124-42-5) + 1,2,3-triazine (289-96-3) → 2-methylpyrimidine (5053-43-0)

Guidance literature:

acetamidine hydrochloride; With sodium methylate; In methanol;

1,2,3-triazine; In [D₃]acetonitrile; at 25 ℃; for 0.0833333h; regioselective reaction;

DOI:10.1021/ol2007428

Reference yield: 93.0%

acetamidine (143-37-3) + 1,2,3-triazine (289-96-3) → 2-methylpyrimidine (5053-43-0)

Guidance literature:

for 0.0833333h; regiospecific reaction;

DOI:10.1021/ja204856a

Reference yield: 65.0%

2-methyl-1,4,5,6-tetrahydropyrimidine (4271-95-8) → 2-methylpyrimidine (5053-43-0)

Guidance literature:

palladium/alumina; at 320 - 350 ℃;

upstream raw materials:

4-chloro-2-methylpyrimidine

2,4-dichloro-2-methylpyrimidine

malonaldehydebis(dimethylacetal)

acetamidine hydrochloride

Downstream raw materials:

2,4-dimethylpyrimidine

4,6-dimethylpyrimidine

2,4,6-trimethylpyrimidine

2-<(E)-2-(N,N-dimethylamino)ethenyl>pyrimidine

Refernces

• 1、 Okada,Morita,Tsuchiya. "Formation of 2-ethylpyrimidine from trimethylenediamine over platinum group metal-A1203 caralysts and its kinetics study (author's transl)". . p. 801 - 809. Retrieved 1976.
• 2、 ?turala, Ji?í,Bohá?ová, Soňa,Chudoba, Josef,Metelková, Radka,Cibulka, Radek. "Electron-deficient heteroarenium salts: An organocatalytic tool for activation of hydrogen peroxide in oxidations". . p. 2676 - 2699. Retrieved 2015/03/18.
• 3、 Anderson, Erin D.,Boger, Dale L.. "Inverse electron demand diels-alder reactions of 1,2,3-triazines: Pronounced substituent effects on reactivity and cycloaddition scope". supporting information; experimental part. p. 12285 - 12292. Retrieved 2011/09/16.