A77 1726

Base Information

Chemical Name:A77 1726
CAS No.:108605-62-5
Molecular Formula:C₁₂H₉F₃N₂O₂
Molecular Weight:270.211
Hs Code.:2926900005
Mol file:108605-62-5.mol

Synonyms:2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide;2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide; Malononitrilamide

Suppliers and Price of A77 1726

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Teriflunomide
50mg
$ 389.00

TRC
A771726(E/Z)Mixture
50mg
$ 80.00

Tocris
Teriflunomide ≥99%(HPLC)
50
$ 151.00

Sigma-Aldrich
Teriflunomide ≥98% (HPLC)
50 mg
$ 262.00

Sigma-Aldrich
Teriflunomide ≥98% (HPLC)
10 mg
$ 61.60

Sigma-Aldrich
Leflunomide Related Compound B United States Pharmacopeia (USP) Reference Standard
20mg
$ 1160.00

Medical Isotopes, Inc.
LeflunomideEPImpurityB
100 mg
$ 290.00

Medical Isotopes, Inc.
LeflunomideEPImpurityB
500 mg
$ 490.00

Labseeker
Teriflunamide 98
10g
$ 650.00

CSNpharm
Teriflunomide(RandomConfiguration)
250mg
$ 140.00

Total 95 raw suppliers

Chemical Property of A77 1726

Chemical Property:

Appearance/Colour:White solid.
Vapor Pressure:6.63E-06mmHg at 25°C
Melting Point:229-232°C
Boiling Point:410.8 °C at 760 mmHg
PKA:5.20±0.50(Predicted)
Flash Point:202.3 °C
PSA：73.12000
Density:1.424 g/cm³
LogP:3.07248
Storage Temp.:+2C to +8C
Solubility.:Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).

Purity/Quality:

99% ^*data from raw suppliers

Teriflunomide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Description Teriflunomide (Aubagio?), also known as A77 1726, is an immunosupressant marketed by Sanofi for the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced B and T cell proliferation.
Uses The active metabolite of Leflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide can be used as a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis.
Clinical Use Immunomodulating agent: Treatment of relapsing remitting multiple sclerosis
Drug interactions Potentially hazardous interactions with other drugs Lipid-lowering agents: effect significantly reduced by colestyramine - avoid; concentration of rosuvastatin increased - consider reducing rosuvastatin dose. Live vaccines: risk of generalised infections - avoid.

Technology Process of A77 1726

There total 14 articles about A77 1726 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75706-12-6
Leflunomide

: 163451-81-8,108605-62-5
teriflunomide

Guidance literature:: Leflunomide; With sodium hydroxide; In water; isopropyl alcohol; at 30 ℃; pH=12;

With hydrogenchloride; at 30 ℃;

Reference yield: 92.0%

: 24522-30-3
2-cyano-N-(4-trifluoromethylphenyl)acetamide

: 108-24-7
acetic anhydride

: 163451-81-8,108605-62-5
teriflunomide

Guidance literature:: 2-cyano-N-(4-trifluoromethylphenyl)acetamide; With sodium hydroxide; In water; acetone; at 15 ℃;

acetic anhydride; In water; acetone; at 15 ℃; for 8.5h;

With hydrogenchloride; In water; at 5 - 10 ℃; for 2h; Product distribution / selectivity;

Reference yield: 88.3%

: 24522-30-3
2-cyano-N-(4-trifluoromethylphenyl)acetamide

: 75-36-5
acetyl chloride

: 163451-81-8,108605-62-5
teriflunomide

Guidance literature:: 2-cyano-N-(4-trifluoromethylphenyl)acetamide; With sodium hydride; In acetonitrile; for 0.166667h;

acetyl chloride; In acetonitrile; at 25 ℃; Cooling;