Technology Process of Bromoclenbuterol
There total 5 articles about Bromoclenbuterol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butylamine; 4-amino-3-bromo-5-chlorobromoacetophenone;
In
tetrahydrofuran; ethanol;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
With
potassium borohydride;
In
tetrahydrofuran; ethanol;
for 2h;
Cooling with ice;
With
methanol;
In
tetrahydrofuran; ethanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C
2.1: copper(ll) bromide / ethyl acetate; chloroform; ethanol / 2 h / Reflux
3.1: ethanol; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3.2: 2 h / Cooling with ice
With
N-Bromosuccinimide; copper(ll) bromide;
In
tetrahydrofuran; ethanol; chloroform; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(ll) bromide / ethyl acetate; chloroform; ethanol / 2 h / Reflux
2.1: ethanol; tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
2.2: 2 h / Cooling with ice
With
copper(ll) bromide;
In
tetrahydrofuran; ethanol; chloroform; ethyl acetate;
