N-p-Tolyl-MalonaMic acid ethyl ester

Base Information

• Chemical Name: N-p-Tolyl-MalonaMic acid ethyl ester
• CAS No.: 72324-44-8
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Mol file: 72324-44-8.mol

Synonyms:ethyl 3-oxo-3-(4-tolylamino)propanoate;N-p-Tolyl-malonamidsaeure-aethylester;ethyl 3-oxo-3-(4-toluidino)propanoate;p-toluidide of monoethyl malonate;ethyl p-methylmalonanilate;ethyl 2-(p-methylanilido)ethanoate;N-(p-tolyl)malonamic acid ethyl ester;

Chemical Property of N-p-Tolyl-MalonaMic acid ethyl ester

Chemical Property:

• Vapor Pressure: 2.64E-06mmHg at 25°C
• Boiling Point: 390.5°C at 760 mmHg
• Flash Point: 190°C
• PSA: 55.40000
• Density: 1.153g/cm³
• LogP: 1.95970

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-3-OXO-3-(4-TOLUIDINO)PROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-p-Tolyl-MalonaMic acid ethyl ester

There total 7 articles about N-p-Tolyl-MalonaMic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

p-toluidine (106-49-0,12221-03-3) + ethyl chlorocarbonylacetate (36239-09-5) → ethyl 2-(p-methylanilido)ethanoate (72324-44-8)

Guidance literature:

With triethylamine; In acetone; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2011.06.054

Reference yield: 13.0%

ethanol (64-17-5) + (2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-p-tolylamino-acetonitrile (270577-95-2) → ethyl 2-(p-methylanilido)ethanoate (72324-44-8) + 5-[(ethoxy)(4-tolylamino)methylene]-2,2-di-methyl-1,3-dioxane-4,6-dione

Guidance literature:

for 72h; Heating;

DOI:10.1016/S0040-4039(02)00467-7

Reference yield:

p-toluidine (106-49-0,12221-03-3) + diethyl malonate (105-53-3) → ethyl 2-(p-methylanilido)ethanoate (72324-44-8) + 4-Methylacetanilide (103-89-9)

Guidance literature:

at 100 - 130 ℃;

DOI:10.1080/00397911.2012.717671

upstream raw materials:

ethanol

N-p-tolyl-malonamic acid

p-toluidine

ethyl chlorocarbonylacetate

Downstream raw materials:

N-p-tolyl-malonamic acid

4-ethoxy-6-methyl-quinolin-2-ol

N-methyl-N'-p-tolyl-malonamide

N-benzyl-N'-(4-methylphenyl)malondiamide