BENZAMIDE, p-AMINO-N-(6-METHYL-2-PYRIDYL)-

Base Information

• Chemical Name: BENZAMIDE, p-AMINO-N-(6-METHYL-2-PYRIDYL)-
• CAS No.: 36845-08-6
• Molecular Formula: C13H13N3O
• Molecular Weight: 227.266
• European Community (EC) Number: 869-134-2
• DSSTox Substance ID: DTXSID40190318
• Nikkaji Number: J54.648H
• Wikidata: Q83062673
• Mol file: 36845-08-6.mol

Synonyms:4-amino-N-(6-methylpyridin-2-yl)benzamide;36845-08-6;BENZAMIDE, p-AMINO-N-(6-METHYL-2-PYRIDYL)-;6-(p-Aminobenzamido)-2-picoline;BRN 0401511;2-Picoline, 6-(p-aminobenzamido)-;Pyridine, 2-(p-aminobenzamido)-6-methyl-;5-22-09-00222 (Beilstein Handbook Reference);BAS 00875488;DTXSID40190318;AKOS000204826;LS-25587;4-Amino-N-(6-methyl-2-pyridyl)benzamide;4-amino-N-(6-methyl-2-pyridinyl)benzamide;CS-0232600;Benzamide, 4-amino-N-(6-methyl-2-pyridinyl)-;EN300-12773991;SR-01000318785;SR-01000318785-1;Z319445248

Chemical Property of BENZAMIDE, p-AMINO-N-(6-METHYL-2-PYRIDYL)-

Chemical Property:

• Vapor Pressure: 6.18E-05mmHg at 25°C
• Boiling Point: 345.4°Cat760mmHg
• Flash Point: 162.7°C
• PSA: 68.01000
• Density: 1.261g/cm³
• LogP: 2.87870
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 227.105862047
• Heavy Atom Count: 17
• Complexity: 261

Purity/Quality:

95% ^*data from raw suppliers

6-(PARA-AMINOBENZAMIDO)-2-PICOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)NC(=O)C2=CC=C(C=C2)N

Technology Process of BENZAMIDE, p-AMINO-N-(6-METHYL-2-PYRIDYL)-

There total 6 articles about BENZAMIDE, p-AMINO-N-(6-METHYL-2-PYRIDYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-nitro-N-(6-methylpyridin-2-yl)benzamide (37586-00-8) → 2-(4-aminobenzoylamino)-6-methyl-pyridine (36845-08-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; under 760.051 Torr;

DOI:10.1021/jacs.9b06697 DOI:10.1021/jacs.9b06697

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 2-(4-aminobenzoylamino)-6-methyl-pyridine (36845-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: H₂ / Pd-C / ethanol

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1016/j.molstruc.2005.09.032

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → 2-(4-aminobenzoylamino)-6-methyl-pyridine (36845-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 20 °C

2: 89 percent / H₂ / Pd/C / ethanol / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; 1: Acylation / 2: Reduction;

DOI:10.1021/jo9909204

upstream raw materials:

4-nitro-N-(6-methylpyridin-2-yl)benzamide

2-Amino-6-methylpyridine

4-nitro-benzoyl chloride

Downstream raw materials:

C₂₂H₁₉N₃O₃