Glycinamide, glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-, hydrate (2:1)

Base Information

Chemical Name:Glycinamide, glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-, hydrate (2:1)
CAS No.:59179-79-2
Molecular Formula:C18H18ClN3O3
Molecular Weight:359.8068
Hs Code.:
DSSTox Substance ID:DTXSID10207907
Wikidata:Q83081918

Synonyms:Glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide hydrate (2:1);Glycinamide, glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-, hydrate (2:1);Glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide hemihydrate;2-Benzoyl-4-chloro-N-methyl-N(sup alpha)-glycylglycinanilide hemihydrate;59179-79-2;SCHEMBL11315144;DTXSID10207907;C18H18ClN3O3.1/2H2O;LS-72195

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycinamide, glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-, hydrate (2:1)

Chemical Property:

Vapor Pressure:2.55E-14mmHg at 25°C
Boiling Point:599.2°Cat760mmHg
Flash Point:316.2°C
Density:1.314g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:359.1036691
Heavy Atom Count:25
Complexity:494

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CC(=O)NC(=O)CN)C1=C(C=C(C=C1)Cl)C(=O)C2=CC=CC=C2

Technology Process of Glycinamide, glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-, hydrate (2:1)

There total 5 articles about Glycinamide, glycyl-N-(2-benzoyl-4-chlorophenyl)-N-methyl-, hydrate (2:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.7%

: 59180-10-8
N-Benzyloxycarbonyl-glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid

: 59179-79-2
Glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid

Guidance literature:: With hydrogen bromide; In acetic acid; for 1.5h; Ambient temperature;
DOI:10.1021/jm00181a013

Reference yield: 78.0%

: 59179-76-9
2-benzoyl-4-chloro-N-methyl-N^α-(tritylglycyl)glycinanilide

: 59179-79-2
Glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid

Guidance literature:: With acetic acid; for 0.333333h; Heating;
DOI:10.1021/jm00181a013

Reference yield:

: 13386-35-1
2-methylamino-5-chlorobenzhydrol

: 59179-79-2
Glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HMPA, SOCl₂ / 1.) CH₃CN, -18 deg C, 30 min, 2.) CH₃CN, -20 deg C, overnight

2: 90.3 percent / Jones reagent / acetone

3: 82.7 percent / 21.8percent HBr / acetic acid / 1.5 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; jones reagent; hydrogen bromide; In acetic acid; acetone;
DOI:10.1021/jm00181a013