{[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester
• CAS No.: 59180-31-3
• Molecular Formula: C₂₆H₂₆ClN₃O₅
• Molecular Weight: 495.963
• Mol file: 59180-31-3.mol

Synonyms:{[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester

Chemical Property of {[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester

There total 1 articles about {[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CbzGlyGly (2566-19-0) + 2-methylamino-5-chlorobenzhydrol (13386-35-1) → {[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester (59180-31-3)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; Yield given. Multistep reaction; 1.) CH₃CN, -18 deg C, 30 min, 2.) CH₃CN, -20 deg C, overnight;

DOI:10.1021/jm00181a013

Reference yield: 90.3%

{[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester (59180-31-3) → N-Benzyloxycarbonyl-glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid (59180-10-8)

Guidance literature:

With jones reagent; In acetone;

DOI:10.1021/jm00181a013

Reference yield:

{[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester (59180-31-3) → Glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid (59179-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.3 percent / Jones reagent / acetone

2: 82.7 percent / 21.8percent HBr / acetic acid / 1.5 h / Ambient temperature

With jones reagent; hydrogen bromide; In acetic acid; acetone;

DOI:10.1021/jm00181a013

upstream raw materials:

CbzGlyGly

2-methylamino-5-chlorobenzhydrol

Downstream raw materials:

N-Benzyloxycarbonyl-glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid

Glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid