13386-35-1

Upstream product

• 67-56-1 methanol 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 1022-13-5 5-chloro-2-(methylamino)benzophenone 

Downstream Products

• 59180-31-3 {[({[4-Chloro-2-(hydroxy-phenyl-methyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-methyl}-carbamic acid benzyl ester 
• 1022-13-5 5-chloro-2-(methylamino)benzophenone 
• 52468-36-7 Diazepam hydrochloride 
• 132735-29-6 6-Chloro-1-methyl-2-<2-(4-nitrobenzylidene)-hydrazino>-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide 
• 132735-30-9 6-Chloro-1-methyl-2-<2-(2-nitrobenzylidene)-hydrazino>-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide 
• 132735-28-5 2-(2-Benzylidenehydrazino)-6-chloro-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide 
• 132735-27-4 6-Chloro-2-(2-ethylidenehydrazino)-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide 
• 132735-19-4 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide 
• 132735-22-9 6-Chloro-2-hydrazino-1-methyl-4-phenyl-1,4-dihydroquinazoline hydroiodide 
• 82669-33-8 ((3S,5R)-7-Chloro-1-methyl-2-oxo-5-phenyl-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl)-acetic acid ethyl ester 
• 82669-33-8 ((3R,5R)-7-Chloro-1-methyl-2-oxo-5-phenyl-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl)-acetic acid ethyl ester 
• 59180-10-8 N-Benzyloxycarbonyl-glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid 
• 59179-79-2 Glycyl-N-(2-benzoyl-4-chlor-phenyl)-N-methyl-glycinamid 
• 26772-95-2 6-chloro-1-methyl-4-phenyl-3,4-dihydro-1H-quinazolin-2-one 

Relevant academic research and scientific papers

Ru-Catalyzed Selective Catalytic Methylation and Methylenation Reaction Employing Methanol as the C1 Source

Methanol can be employed as a green and sustainable methylating agent to form C-C and C-N bonds via borrowing hydrogen (BH) methodology. Herein we explored the activity of the acridine-derived SNS-Ru pincer for the activation of methanol to apply it as a C1 building block in different reactions. Our catalytic system shows great success toward the β-C(sp3)-methylation reaction of 2-phenylethanols to provide good to excellent yields of the methylated products. We investigated the mechanistic details, kinetic progress, and temperature-dependent product distribution, which revealed the slow and steady generation of in situ formed aldehyde, is the key factor to get the higher yield of the β-methylated product. To establish the environmental benefit of this reaction, green chemistry metrics are calculated. Furthermore, dimerization of 2-naphthol via methylene linkage and formation of N-methylation of amine are also described in this study, which offers a wide range of substrate scope with a good to excellent yield.

Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies

A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N1-oxide exhibited interesting antichagasic activity on the two parasitic strains

Ureas in Organic Synthesis. XII. Syntesis of 2-Amino-5-chlorobenzhydrylureas and Their Heterocyclization

A synthetic method was developed for hard-to-get biologically active 2-amino-5-chlorobenzhydrylureas based on reaction of the corresponding benzhydrols with urea in sulfuric acid. The 2-amino-5-chlorobenzhydrylureas were shown to easily undergo on heating cyclization to 1-R-1,2,3,4-tetrahydro-4-phenyl-chloroquinazolin-2-ones.

Process for the production of o-(N-monosubstituted amino)benzyl alcohols

Process for the production of o-(N-monosubstituted amino)benzyl alcohols which comprises reacting an N-mono-substituted aniline optionally having one or more substituents with a boron trihalogenide at a temperature from about 0° C. to about 100° C. and reacting the resultant boron compound with an aldehyde in the presence of a base at a temperature from about -30° C. to about 100° C. to regiospecifically introduce a 1-hydroxy-alkyl or 1-hydroxy-substituted alkyl group into the ortho position of said aniline.