1-[(4-Methylphenyl)sulfonyl]-2,3,4,5-tetrahydro-1h-1-benzazepin-5-ol

Base Information

Chemical Name:1-[(4-Methylphenyl)sulfonyl]-2,3,4,5-tetrahydro-1h-1-benzazepin-5-ol
CAS No.:19673-33-7
Molecular Formula:C17H19 N O3 S
Molecular Weight:317.4027
Hs Code.:
NSC Number:105658
DSSTox Substance ID:DTXSID40295832

Synonyms:19673-33-7;1-[(4-methylphenyl)sulfonyl]-2,3,4,5-tetrahydro-1h-1-benzazepin-5-ol;NSC105658;Oprea1_546485;DTXSID40295832;NSC-105658

Suppliers and Price of 1-[(4-Methylphenyl)sulfonyl]-2,3,4,5-tetrahydro-1h-1-benzazepin-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 1-[(4-Methylphenyl)sulfonyl]-2,3,4,5-tetrahydro-1h-1-benzazepin-5-ol

Chemical Property:

Vapor Pressure:2.64E-10mmHg at 25°C
Boiling Point:487.2°Cat760mmHg
Flash Point:248.4°C
Density:1.292g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:317.10856464
Heavy Atom Count:22
Complexity:465

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N2CCCC(C3=CC=CC=C32)O

Technology Process of 1-[(4-Methylphenyl)sulfonyl]-2,3,4,5-tetrahydro-1h-1-benzazepin-5-ol

There total 4 articles about 1-[(4-Methylphenyl)sulfonyl]-2,3,4,5-tetrahydro-1h-1-benzazepin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24310-36-9
1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

: 19673-33-7
5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 4h;

Reference yield:

: 1127-74-8
1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one

: 19673-33-7
5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 0 °C

2: NaBH₄ / tetrahydrofuran / 4 h / 0 °C

With pyridine; sodium tetrahydroborate; In tetrahydrofuran; 1: Tosylation / 2: Reduction;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 19673-33-7
5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 0 °C

2: NaBH₄ / tetrahydrofuran / 4 h / 0 °C

With pyridine; sodium tetrahydroborate; In tetrahydrofuran; 1: Tosylation / 2: Reduction;