phenyl pyridine-2-carboxylate

Base Information

• Chemical Name: phenyl pyridine-2-carboxylate
• CAS No.: 26838-86-8
• Molecular Formula: C12H9 N O2
• Molecular Weight: 199.209
• Mol file: 26838-86-8.mol

Synonyms:Picolinic acid, phenyl ester (8CI); Phenyl2-pyridinecarboxylate; Phenyl picolinate

Chemical Property of phenyl pyridine-2-carboxylate

Chemical Property:

• Vapor Pressure: 9.51E-05mmHg at 25°C
• Boiling Point: 338.9°Cat760mmHg
• Flash Point: 158.8°C
• Density: 1.199g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyl pyridine-2-carboxylate

There total 14 articles about phenyl pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-pyridine (109-04-6) + phenyl formate (1864-94-4) → pyridine-2-carboxylic acid phenyl ester (26838-86-8)

Guidance literature:

With palladium diacetate; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In acetonitrile; at 80 ℃; Inert atmosphere;

DOI:10.1021/ol301192s

Reference yield: 99.0%

→ pyridine-2-carboxylic acid phenyl ester (26838-86-8)

Guidance literature:

With thionyl chloride; for 1h; Reflux;

With dmap; triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 87.0%

2-iodopyridine (5029-67-4) + phenyl formate (1864-94-4) → pyridine-2-carboxylic acid phenyl ester (26838-86-8)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In acetonitrile; at 20 ℃; for 6h;

DOI:10.1002/adsc.201700751

upstream raw materials:

phenol

pyridine-2-carbonyl chloride

2-Picolinic acid

2-bromo-pyridine

Downstream raw materials:

2-Picolinic acid

phenol

(2-hydroxyphenyl)(pyridin-2-yl)methanone

(4-hydroxyphenyl)(pyridin-2-yl)methanone

Refernces

• 1、 -. "Method of coupling, and the coupling method using the aromatic group-substituted heterocyclic compound". Paragraph 0202-0207. . Retrieved 2020/09/17.
• 2、 -. "N-(3,5-dimethyladamantane-1-yl)-N'-substituted phenylurea compound as well as preparation method and application thereof". Paragraph 0072; 0073; 0120; 0121. . Retrieved 2017/12/28.