AURORA 52

Base Information

• Chemical Name: AURORA 52
• CAS No.: 39887-24-6
• Molecular Formula: C15H14 Cl N O
• Molecular Weight: 259.735
• Hs Code.: 2924299090
• Mol file: 39887-24-6.mol

Synonyms:Benzamide,p-chloro-N-phenethyl- (6CI); 4-Chloro-N-phenethylbenzamide; NSC 204159

Chemical Property of AURORA 52

Chemical Property:

• Vapor Pressure: 4.63E-08mmHg at 25°C
• Boiling Point: 443.5°Cat760mmHg
• Flash Point: 222°C
• PSA: 29.10000
• Density: 1.186g/cm³
• LogP: 3.70340

Purity/Quality:

99% ^*data from raw suppliers

4-CHLORO-N-PHENETHYLBENZAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AURORA 52

There total 19 articles about AURORA 52 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phenethylamine (64-04-0) + para-chlorobenzoic acid (74-11-3) → N-(2-phenylethyl)-p-chlorobenzamide (39887-24-6)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1248/cpb.55.825

Reference yield: 94.1%

4-chloro-benzoyl chloride (122-01-0) + phenethylamine (64-04-0) → N-(2-phenylethyl)-p-chlorobenzamide (39887-24-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2.33333h;

Reference yield: 93.0%

1,3-dioxoisoindolin-2-yl 4-chlorobenzoate (63591-89-9) + phenethylamine (64-04-0) → N-(2-phenylethyl)-p-chlorobenzamide (39887-24-6)

Guidance literature:

With ethyl acetate; at 20 ℃; for 3h;

DOI:10.1039/c6ra22653a

upstream raw materials:

4-chloro-benzoyl chloride

phenethylamine

3-(4-Chlorobenzoyl)-2-oxazolidinone

para-chlorobenzoic acid

Downstream raw materials:

3-<4-(2-(4-chlorobenzoyl)aminoethyl)-benzoyl>acrylic acid

N-phenethylbenzamide

2-(4-chlorophenyl)-5-phenyloxazole

2-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1,3-oxazole

Refernces

• 1、 Burnett, Duane A.,Chen, Angela Y.-P.,Koenig, Gerhard,Lanter, James C.,Williamson, Toni,Blain, Jean-Fran?ois. "Discovery of quinuclidine modulators of cellular progranulin". . . Retrieved 2021/06/30.
• 2、 Schuhmacher, Anne,Ryan, Sarah J.,Bode, Jeffrey W.. "Catalytic Synthesis of Potassium Acyltrifluoroborates (KATs) from Boronic Acids and the Thioimidate KAT Transfer Reagent". supporting information. p. 3918 - 3922. Retrieved 2020/12/23.