100423-00-5Relevant academic research and scientific papers
Efficient preparation of biologically important 1,2-amino alcohols
Gupta, Pankaj,Rouf, Abdul,Shah, Bhahwal A.,Mukherjee, Debaraj,Taneja, Subhash C.
, p. 505 - 519 (2013/01/15)
An efficient three-step methodology developed for the preparation of 1,2-amino alcohols. In the first step a rapid coupling between bromoketones and potassium phthalimide in ionic liquid produced-phthalimido ketones in quantitative yields, which is followed by a facile reduction using NaCNBH 3 in acetic acid to give corresponding phthalimido alcohols and finally effecting hydrazinolysis in water at 60C to yield biologically important 1,2-amino alcohols.
An efficient protocol for the reduction of ketones with tin(II) complexes and PMHS
Lawrence, Nicholas J.,Bushell, Simon M.
, p. 4507 - 4512 (2007/10/03)
A mixture of tin(II) triflate/pybox and polymethylhydrosiloxane (PMHS) in methanol effects the efficient reduction of ketones; the use of an enantiomerically pure pybox ligand leads to moderate enantioselectivity. (C) 2000 Elsevier Science Ltd.
Nucleophilic Aminomethylation of Aldehydes with α-Amino Alkylsilanes
Tsuge, Otohiko,Tanaka, Junji,Kanemasa, Shuji
, p. 1991 - 1999 (2007/10/02)
Fluoride-induced desilylation of (α-phthalimido-, α-morpholino-, and α-acetamidobenzyl)silanes and a (phthalimidomethyl)silane generates the corresponding α-amino carbanions which add to a variety of aldehydes.The conversion of phthalimido group of the adducts into amino moiety leads to β-amino alcohols.This simple reaction sequence offers a new and general method of nucleophilic aminomethylation.
