2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione

Base Information

• Chemical Name: 2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione
• CAS No.: 100423-00-5
• Molecular Formula: C₁₇H₁₅NO₄
• Molecular Weight: 297.31
• Mol file: 100423-00-5.mol

Synonyms:2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione

Chemical Property of 2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione

There total 3 articles about 2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-[2-(4-methoxyphenyl)-2-oxo-ethyl]-isoindole-1,3-dione (970-56-9) → 2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione (100423-00-5)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 20 ℃; for 24h;

DOI:10.1080/00397911.2011.603876

Reference yield: 22.0%

N-<(Trimethylsilyl)methyl>phthalimide (18042-62-1) + 4-methoxy-benzaldehyde (123-11-5) → N-methylphthalimide (550-44-7) + 2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione (100423-00-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

DOI:10.1246/bcsj.58.1991

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione (100423-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.22 h / 20 °C / Ionic liquid

2: sodium cyanoborohydride; acetic acid / 24 h / 20 °C

With sodium cyanoborohydride; acetic acid;

DOI:10.1080/00397911.2011.603876

upstream raw materials:

N-<(Trimethylsilyl)methyl>phthalimide

4-methoxy-benzaldehyde

2-[2-(4-methoxyphenyl)-2-oxo-ethyl]-isoindole-1,3-dione

2-Bromo-4'-methoxyacetophenone

Downstream raw materials:

2-amino-1-(4-methoxyphenyl)ethanol