(4-METHOXY-PHENYL)-OXO-ACETONITRILE

Base Information

• Chemical Name: (4-METHOXY-PHENYL)-OXO-ACETONITRILE
• CAS No.: 14271-83-1
• Molecular Formula: C9H7 N O2
• Molecular Weight: 161.16
• Hs Code.: 2926909090
• Mol file: 14271-83-1.mol

Synonyms:Glyoxylonitrile,(p-methoxyphenyl)- (7CI,8CI); 4-Methoxy-a-oxobenzeneacetonitrile; 4-Methoxybenzoyl cyanide;p-Anisoyl cyanide; p-Methoxybenzoyl cyanide

Chemical Property of (4-METHOXY-PHENYL)-OXO-ACETONITRILE

Chemical Property:

• Melting Point: 63-64 °C
• Boiling Point: 271.3±23.0 °C(Predicted)
• PSA: 50.09000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 1.40148
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-MethoxybenzoylCyanide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-METHOXY-PHENYL)-OXO-ACETONITRILE

There total 36 articles about (4-METHOXY-PHENYL)-OXO-ACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-methoxyphenylglyoxal (1076-95-5) → 4-methoxybenzoyl cyanide (14271-83-1)

Guidance literature:

With 1-amino-2-oxo-4,6-diphenylpyridine; In toluene; at 110 ℃; for 6h;

DOI:10.1055/s-1980-29233

Reference yield: 91.0%

2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile (66985-48-6) → 4-methoxybenzoyl cyanide (14271-83-1)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; at 18 ℃; for 0.666667h; Irradiation;

Reference yield: 89.0%

trimethylsilyl cyanide (7677-24-9) + 4-methoxy-benzoyl chloride (100-07-2) → 4-methoxybenzoyl cyanide (14271-83-1)

Guidance literature:

tin(IV) chloride; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1055/s-1983-30453

upstream raw materials:

4-methoxymandelonitrile

p-methoxy-isonitrosoacetophenone

acetic anhydride

hydrogen cyanide

Downstream raw materials:

2-(4-methoxyphenyl)-1,1,2-tricyanoethylene

1-(4-methoxyphenyl)-3-phenylpropane-1,3-dione

2-amino-1-(4-methoxyphenyl)ethanol

4-methoxybenzoic acid

Refernces

• 1、 -. "Novel synthesis method of alpha-carbonyl acid ester". . . Retrieved 2020/07/21.
• 2、 Lu, Hao,Li, Zheng. "Palladium-Catalyzed One-Pot Four-Component Synthesis of β-Cyano-α,β-unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source". supporting information. p. 4474 - 4482. Retrieved 2019/08/20.