Technology Process of gamma-Methoxy-4-methylbenzenebutanenitrile
There total 6 articles about gamma-Methoxy-4-methylbenzenebutanenitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methanol;
With
tetrakis(actonitrile)copper(I) hexafluorophosphate; tert-butyl XPhos;
at 20 ℃;
for 0.25h;
Schlenk technique;
Inert atmosphere;
2-(p-tolyl)cyclobutan-1-one O-(4-(trifluoromethyl)benzoyl)oxime;
at 60 ℃;
for 5h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b03707
- Guidance literature:
-
With
tris[2-phenylpyridinato-C2,N]iridium(III); sodium hydrogencarbonate;
at 20 ℃;
for 24h;
Inert atmosphere;
Irradiation;
DOI:10.1002/adsc.201400548
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 70 °C / Inert atmosphere
1.2: Inert atmosphere; Reflux
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere
3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 12 h / 75 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
5.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; tert-butyl XPhos / 0.25 h / 20 °C / Schlenk technique; Inert atmosphere
5.2: 5 h / 60 °C / Schlenk technique; Inert atmosphere
With
tetrakis(actonitrile)copper(I) hexafluorophosphate; hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tert-butyl XPhos;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.orglett.7b03707
