4-(Cyclohexyloxy)-4-oxobutanoic acid

Base Information

• Chemical Name: 4-(Cyclohexyloxy)-4-oxobutanoic acid
• CAS No.: 10018-78-7
• Molecular Formula: C10H16 O4
• Molecular Weight: 200.235
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID40905242
• Wikidata: Q82873653
• Mol file: 10018-78-7.mol

Synonyms:4-(cyclohexyloxy)-4-oxobutanoic acid;10018-78-7;Cyclohexanol succinate;Radioplex;4-cyclohexyloxy-4-oxobutanoic acid;Butanedioic acid,1-cyclohexyl ester;Succinic acid, monocyclohexyl ester;BRN 2558695;Succinic acid monocyclohexyl ester;cyclo-hexyl hydrogen succinate;SCHEMBL3472508;DTXSID40905242;4-(cyclohexyloxy)-4-oxobutanoate;4-(cyclohexyloxy)-4-oxobutanoicacid;MFCD00785959;STL064937;AKOS000498440;AS-62514;CS-0155320

Chemical Property of 4-(Cyclohexyloxy)-4-oxobutanoic acid

Chemical Property:

• Vapor Pressure: 1.41E-05mmHg at 25°C
• Boiling Point: 341.9°Cat760mmHg
• Flash Point: 132.6°C
• PSA: 63.60000
• Density: 1.15g/cm³
• LogP: 1.72710
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 200.10485899
• Heavy Atom Count: 14
• Complexity: 206

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Cyclohexyloxy)-4-oxobutanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)OC(=O)CCC(=O)O

Technology Process of 4-(Cyclohexyloxy)-4-oxobutanoic acid

There total 3 articles about 4-(Cyclohexyloxy)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

cyclohexyl acrylate (3066-71-5,27458-65-7) + cesium formate (3495-36-1) → cyclohexyl hemisuccinate (10018-78-7)

Guidance literature:

With eosin B disodium salt; In dimethyl sulfoxide; at 100 ℃; for 12h; Inert atmosphere; Irradiation;

DOI:10.1021/acscatal.1c04684

Reference yield:

succinic acid anhydride (108-30-5) + cyclohexanol (108-93-0) → cyclohexyl hemisuccinate (10018-78-7)

Guidance literature:

at 140 ℃;

Reference yield:

succinic acid (110-15-6) + cyclohexanol (108-93-0) → cyclohexyl hemisuccinate (10018-78-7)

Guidance literature:

at 180 - 200 ℃;

upstream raw materials:

succinic acid anhydride

cyclohexanol

succinic acid

cyclohexyl acrylate

Downstream raw materials:

3-cyclohexyloxycarbonylpropionyl chloride

Refernces