2,2,2-Trichloroethyl phosphorodichloridite

Base Information

• Chemical Name: 2,2,2-Trichloroethyl phosphorodichloridite
• CAS No.: 60010-51-7
• Molecular Formula: C2H2 Cl5 O P
• Molecular Weight: 250.276
• Hs Code.: 2909199090
• European Community (EC) Number: 262-021-3
• UNII: VJ43RN75ZA
• DSSTox Substance ID: DTXSID70208718
• Nikkaji Number: J298.757K
• Wikidata: Q83082846
• Mol file: 60010-51-7.mol

Synonyms:2,2,2-TCE PPDC;2,2,2-trichloroethyl phosphorodichloridite

Chemical Property of 2,2,2-Trichloroethyl phosphorodichloridite

Chemical Property:

• Vapor Pressure: 0.0298mmHg at 25°C
• Refractive Index: n20/D 1.521(lit.)
• Boiling Point: 42 °C/0.1 mmHg(lit.)
• Flash Point: 87.6°C
• PSA: 22.82000
• Density: 1.606 g/mL at 25 °C(lit.)
• LogP: 4.07770
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 249.825640
• Heavy Atom Count: 9
• Complexity: 79.5

Purity/Quality:

98%Min ^*data from raw suppliers

2,2,2-TRICHLOROETHYL DICHLOROPHOSPHITE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(Cl)(Cl)Cl)OP(Cl)Cl

Technology Process of 2,2,2-Trichloroethyl phosphorodichloridite

There total 5 articles about 2,2,2-Trichloroethyl phosphorodichloridite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

trimethyl(2,2,2-trichloroethoxy)silane (41262-38-8) → β,β,β-trichloroethyl phosphorodichloridite (60010-51-7)

Guidance literature:

With pyridine; phosphorus trichloride; In dichloromethane; at -65 - 20 ℃; for 336h; Inert atmosphere; Sealed tube;

DOI:10.1080/10426500902719222

Reference yield: 62.0%

dipropyl β,β,β-trichloroethyl phosphite → dipropyl phosphorochloridite (20003-39-8) + β,β,β-trichloroethyl phosphorodichloridite (60010-51-7)

Guidance literature:

With phosphorus trichloride; at 50 - 60 ℃; for 1h;

Reference yield: 15.3%

1,1,1-trichloroethanol (115-20-8) → β,β,β-trichloroethyl phosphorodichloridite (60010-51-7) + bis(2,2,2-trichloroethyl) phosphorochloridite (41662-41-3)

Guidance literature:

With phosphorus trichloride; 1.) -50 deg C, 15 min, 2.) 0 deg C, 2h, 3.) 55 deg C, 15 mmHg, 1h;

DOI:10.1021/jo00333a016

upstream raw materials:

1,1,1-trichloroethanol

trimethyl(2,2,2-trichloroethoxy)silane

Downstream raw materials:

Phosphorochloridous acid 2,2,2-trichloro-ethyl ester (2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester

Phosphorochloridous acid 2,2,2-trichloro-ethyl ester (2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl ester

C₉₁H₁₂₆Cl₉N₈O₃₀P₃Si₄

C₆₆H₈₈Cl₃N₈O₁₃PSi₃

Refernces

• 1、 Gazizov, T. Kh.,Belyalov, R. U.,Pudovik, A. N.. "REACTION OF ESTERS OF PHOSPHOROUS ACID WITH CHLORIDES OF TRIVALENT PHOSPHORUS". . p. 1762 - 1765. Retrieved 2007/10/02.