METHYL PHOSPHORODICHLORIDATE

Base Information

• Chemical Name: METHYL PHOSPHORODICHLORIDATE
• CAS No.: 677-24-7
• Molecular Formula: CH3Cl2O2P
• Molecular Weight: 148.913
• European Community (EC) Number: 211-639-1
• UNII: P5R9XZ7EJU
• DSSTox Substance ID: DTXSID50217984
• Nikkaji Number: J23.983F
• Wikidata: Q59311061
• Mol file: 677-24-7.mol

Synonyms:Methylphosphorodichloridate (6CI,7CI);Dichloromethoxyphosphine oxide;Methoxyphosphoryl dichloride;Methyl dichlorophosphate;Methyldichlorophosphinate;

Chemical Property of METHYL PHOSPHORODICHLORIDATE

Chemical Property:

• Vapor Pressure: 2.21mmHg at 25°C
• Melting Point: -59 °C
• Refractive Index: n20/D 1.436(lit.)
• Boiling Point: 167.8 °C at 760 mmHg
• Flash Point: 3 °C
• PSA: 36.11000
• Density: 1.514 g/cm³
• LogP: 2.21850
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 147.9247717
• Heavy Atom Count: 6
• Complexity: 75.6

Purity/Quality:

>95% ^*data from raw suppliers

Methyl Phosphorodichloridate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COP(=O)(Cl)Cl
• Uses: Methyl dichlorophosphate was used in the synthesis of:4,6-cyclic phosphate tetrasaccharide8-(2′′-hydroxyethoxy)adenosine-5′,2′′-phosphate derivativeanalogs of (R)-1-O-hexadecyl-2-palmitoyl-sn-glycero-3-phosphoethanolamine poly(ethylene glycol)dioxaphosphorino[m,n-x]pyridines compounds

Technology Process of METHYL PHOSPHORODICHLORIDATE

There total 9 articles about METHYL PHOSPHORODICHLORIDATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

O-methyl O-phenyl S-propyl thiophosphate (54262-51-0) → O-Phenyl S-propyl phosphorochloridothiolate (80553-34-0) + methyl dichlorophosphoridate (677-24-7)

Guidance literature:

With trichlorophosphate; at 95 ℃; for 5h;

DOI:10.1080/10426509808029665

Reference yield: 83.0%

methanol (67-56-1) → methyl dichlorophosphoridate (677-24-7)

Guidance literature:

With trichlorophosphate; In diethyl ether; Petroleum ether; 1) 0 deg C, 3h; 2) 12h, 20 deg C; 3) 3h, reflux;

Reference yield: 82.1%

methoxydimethylsilyl cyanide (23272-12-0) → dimethylchlorosilyl cyanide + methyl cyanochlorophosphate + dimethylsilicon dichloride (75-78-5,30107-43-8) + methyl dichlorophosphoridate (677-24-7)

Guidance literature:

With trichlorophosphate; at 45 - 50 ℃; for 0.333333h;

DOI:10.1007/BF00863934

upstream raw materials:

methanol

O,O-dimethyl O-phenyl phosphorothioate

O,O-Dimethyl-O-(p-chlorphenyl)-thiophosphat

phenylthiophosphonic acid dimethyl ester

Downstream raw materials:

phosphoric acid-chloride methyl ester-p-toluidide

Flavin mononucleotide

C₁₁H₁₃N₂O₄P

Methyl-N-p-Chlorphenylphosphoramidin chlorid

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