1-Ethoxy-3-methoxybenzene

Base Information

• Chemical Name: 1-Ethoxy-3-methoxybenzene
• CAS No.: 25783-45-3
• Molecular Formula: C9H12 O2
• Molecular Weight: 152.193
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID80180450
• Nikkaji Number: J88.380H
• Wikidata: Q83050992
• ChEMBL ID: CHEMBL2252480
• Mol file: 25783-45-3.mol

Synonyms:1-Ethoxy-3-methoxybenzene;25783-45-3;1-methoxy-3-ethoxybenzene;Benzene, 1-ethoxy-3-methoxy-;3-Ethoxyanisole;1-Ethoxy-3-methoxybenzene #;SCHEMBL1068417;CHEMBL2252480;DTXSID80180450;AKOS027384619;CS-0450159

Chemical Property of 1-Ethoxy-3-methoxybenzene

Chemical Property:

• Vapor Pressure: 0.176mmHg at 25°C
• Boiling Point: 219.4°Cat760mmHg
• Flash Point: 80°C
• PSA: 18.46000
• Density: 0.988g/cm³
• LogP: 2.09390
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 104

Purity/Quality:

99% ^*data from raw suppliers

1-Ethoxy-3-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC(=C1)OC

Technology Process of 1-Ethoxy-3-methoxybenzene

There total 10 articles about 1-Ethoxy-3-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethanol (64-17-5) + 3-methoxy-1-iodobenzene (766-85-8) → 1-ethoxy-3-methoxybenzene (25783-45-3)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; at 110 ℃; for 20h;

DOI:10.1021/ol025548k

Reference yield: 93.0%

1,10-Phenanthroline (66-71-7) + 3-methoxy-1-iodobenzene (766-85-8) → 1-ethoxy-3-methoxybenzene (25783-45-3)

Guidance literature:

With CuI; caesium carbonate; In ethanol;

Reference yield: 84.0%

triethyl borate (150-46-9) + potassium 4-methoxybenzoate (52509-81-6) → 1-ethoxy-3-methoxybenzene (25783-45-3)

Guidance literature:

With oxygen; copper diacetate; silver carbonate; In N,N-dimethyl-formamide; at 140 ℃; for 36h; under 760.051 Torr;

DOI:10.1002/anie.201208755

upstream raw materials:

O-methylresorcine

ethanol

3-methoxy-1-iodobenzene

ethyl acrylate

Downstream raw materials:

1-Ethoxy-2-ethylsulfanyl-3-methoxy-benzene

1-Ethoxy-3-methoxy-2-methylsulfanyl-benzene

2-ethoxy-6-methoxyphenylacetaldehyde

(E)-ethyl 4-(2-ethoxy-6-methoxyphenyl)-2-methylcrotonate