1-(6-Chloropyridazin-3-yl)piperidin-4-ol

Base Information

Chemical Name:1-(6-Chloropyridazin-3-yl)piperidin-4-ol
CAS No.:89937-26-8
Molecular Formula:C9H12ClN3O
Molecular Weight:213.66
Hs Code.:2933990090
DSSTox Substance ID:DTXSID901009068
Wikidata:Q72458380
Mol file:89937-26-8.mol

Synonyms:1-(6-Chloropyridazin-3-yl)piperidin-4-ol;89937-26-8;1-(6-Chloro-3-pyridazinyl)-4-piperidinol;MFCD05864736;1-(6-CHLORO-3-PYRIDAZINYL)PIPERIDIN-4-OL;4-PIPERIDINOL, 1-(6-CHLORO-3-PYRIDAZINYL)-;1-(6-Chloropyridazino-3-yl)-4-hydroxypiperidine;SCHEMBL2963749;AMY5254;GYVIZUPSUNWREG-UHFFFAOYSA-N;DTXSID901009068;AKOS003396350;AC-7317;CS-W003253;GS-4499;MB03660;SY005710;FT-0654864;EN300-75074;A843376;1-(6-chloropyridazin-3-yl)piperidin-4-ol, AldrichCPR;F1967-2165;Z108582310;1-(6-CHLORO-PYRIDAZINO-3-YL)-4-HYDROXYPIPERIDINE

Suppliers and Price of 1-(6-Chloropyridazin-3-yl)piperidin-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynChem
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 95%
5 g
$ 150.00

SynChem
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 95%
10 g
$ 240.00

SynChem
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 95%
1 g
$ 50.00

Matrix Scientific
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 95+%
1g
$ 185.00

Matrix Scientific
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 95+%
5g
$ 500.00

Matrix Scientific
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 95+%
10g
$ 714.00

Crysdot
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 97%
10g
$ 199.00

Chemenu
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 97%
25g
$ 337.00

Chemenu
1-(6-Chloropyridazin-3-yl)piperidin-4-ol 97%
10g
$ 204.00

Biosynth Carbosynth
1-(6-Chloropyridazin-3-yl)piperidin-4-ol
5 g
$ 200.00

Total 33 raw suppliers

Chemical Property of 1-(6-Chloropyridazin-3-yl)piperidin-4-ol

Chemical Property:

Vapor Pressure:5.24E-09mmHg at 25°C
Refractive Index:1.599
Boiling Point:453.3 °C at 760 mmHg
PKA:14.52±0.20(Predicted)
Flash Point:228 °C
PSA：49.25000
Density:1.36 g/cm³
LogP:1.15610
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:213.0668897
Heavy Atom Count:14
Complexity:185

Purity/Quality:

97% ^*data from raw suppliers

1-(6-Chloropyridazin-3-yl)piperidin-4-ol 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1O)C2=NN=C(C=C2)Cl

Technology Process of 1-(6-Chloropyridazin-3-yl)piperidin-4-ol

There total 1 articles about 1-(6-Chloropyridazin-3-yl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: 141-30-0
3,6-dichlorpyridazine

: 89937-26-8
1-(6-chloro-pyridazin-3-yl)-piperidin-4-ol

Guidance literature:: With triethylamine; In dimethyl sulfoxide; Sealed tube;
DOI:10.1016/j.bmc.2016.03.009

Reference yield: 51.0%

: 3827-49-4
2-chloro-5-fluoro-phenol

: 89937-26-8
1-(6-chloro-pyridazin-3-yl)-piperidin-4-ol

: 944808-82-6
3-chloro-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1021/jm070219p

Reference yield:

: 89937-26-8
1-(6-chloro-pyridazin-3-yl)-piperidin-4-ol

: 944808-85-9
N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / triphenylphosphine; di-tert-butyl azodicarboxylate / tetrahydrofuran / 2 h / 25 °C

2: 75 percent / [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂(II)*CH₂Cl₂ / 3 h / 100 °C / 10343.2 Torr

3: 95 percent / aq. NaOH / methanol / 3 h / 25 °C

4: 92 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium⁽¹⁺⁾*BF₄^(1-); Et₃N / dimethylformamide / 1 h / 25 °C / pH 6

With sodium hydroxide; di-tert-butyl-diazodicarboxylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂(II)*CH₂Cl₂; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1021/jm070219p