N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Base Information

Chemical Name:N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine
CAS No.:944808-85-9
Molecular Formula:C₁₈H₁₉ClFN₅O₃
Molecular Weight:407.832
Hs Code.:

Synonyms:N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Suppliers and Price of N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

There total 5 articles about N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 944808-24-6
6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carboxylic acid

: 1068-57-1
acetic acid hydrazide

: 944808-85-9
N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 1h; pH=6;
DOI:10.1021/jm070219p

Reference yield:

: 944808-82-6
3-chloro-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine

: 944808-85-9
N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂(II)*CH₂Cl₂ / 3 h / 100 °C / 10343.2 Torr

2: 95 percent / aq. NaOH / methanol / 3 h / 25 °C

3: 92 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium⁽¹⁺⁾*BF₄^(1-); Et₃N / dimethylformamide / 1 h / 25 °C / pH 6

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂(II)*CH₂Cl₂; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070219p

Reference yield:

: 3827-49-4
2-chloro-5-fluoro-phenol

: 944808-85-9
N'-acetyl-6-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]pyridazine-3-carbohydrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / triphenylphosphine; di-tert-butyl azodicarboxylate / tetrahydrofuran / 2 h / 25 °C

2: 75 percent / [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂(II)*CH₂Cl₂ / 3 h / 100 °C / 10343.2 Torr

3: 95 percent / aq. NaOH / methanol / 3 h / 25 °C

4: 92 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium⁽¹⁺⁾*BF₄^(1-); Et₃N / dimethylformamide / 1 h / 25 °C / pH 6

With sodium hydroxide; di-tert-butyl-diazodicarboxylate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂(II)*CH₂Cl₂; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1021/jm070219p