2-hydroxy-N'-(4-methoxybenzylidene)benzohydrazide

Base Information

• Chemical Name: 2-hydroxy-N'-(4-methoxybenzylidene)benzohydrazide
• CAS No.: 3291-01-8
• Molecular Formula: C15H14N2O3
• Molecular Weight: 270.288
• NSC Number: 213591
• DSSTox Substance ID: DTXSID70425903
• ChEMBL ID: CHEMBL1962702
• Mol file: 3291-01-8.mol

Synonyms:2-hydroxy-N'-(4-methoxybenzylidene)benzohydrazide;2-hydroxy-N'-[(E)-(4-methoxyphenyl)methylidene]benzohydrazide;3291-01-8;NSC213591;ST50066439;CHEMBL1962702;DTXSID70425903;STK236464;AKOS000575317;NSC-213591;BRD-K38421537-001-01-9;Z49630543

Chemical Property of 2-hydroxy-N'-(4-methoxybenzylidene)benzohydrazide

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 270.10044231
• Heavy Atom Count: 20
• Complexity: 338

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=NNC(=O)C2=CC=CC=C2O
• Isomeric SMILES: COC1=CC=C(C=C1)/C=N/NC(=O)C2=CC=CC=C2O

Technology Process of 2-hydroxy-N'-(4-methoxybenzylidene)benzohydrazide

There total 7 articles about 2-hydroxy-N'-(4-methoxybenzylidene)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methoxy-benzaldehyde (123-11-5) + 2-Hydroxybenzoylhydrazine (936-02-7) → N'-[(4-methoxyphenyl)methylidene]-2-hydroxybenzohydrazide (3291-01-8)

Guidance literature:

In ethanol; for 5h; Reflux;

DOI:10.1016/j.tetlet.2014.12.037

Reference yield:

N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide (70203-02-0) → N'-[(4-methoxyphenyl)methylidene]-2-hydroxybenzohydrazide (3291-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / water

2: acetic acid / ethanol / Reflux

With sulfuric acid; acetic acid; In ethanol; water;

DOI:10.1002/jhet.2516

Reference yield:

N'-[2-(4-chlorophenyl)-2-ethylidene]-2-hydroxybenzohydrazide → N'-[(4-methoxyphenyl)methylidene]-2-hydroxybenzohydrazide (3291-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / water

2: acetic acid / ethanol / Reflux

With sulfuric acid; acetic acid; In ethanol; water;

DOI:10.1002/jhet.2516

upstream raw materials:

4-methoxy-benzaldehyde

2-Hydroxybenzoylhydrazine

N'-(2-phenyl-2-ethylidene)-2-hydroxybenzohydrazide

methyl salicylate

Downstream raw materials:

4-methoxy-benzaldehyde

2-Hydroxybenzoylhydrazine

N-[2-(4-methoxyphenyl)-4-oxo-1,3-thiazolidin-3-yl]-2-hydroxybenzamide