3-Methyl-1-phenyl-5-(piperidin-1-yl)-1h-pyrazole-4-carbaldehyde

Base Information

Chemical Name:3-Methyl-1-phenyl-5-(piperidin-1-yl)-1h-pyrazole-4-carbaldehyde
CAS No.:5499-70-7
Molecular Formula:C16H19N3O
Molecular Weight:269.346
Hs Code.:2933990090
DSSTox Substance ID:DTXSID00351463
Nikkaji Number:J2.521.264I
Wikidata:Q82127897
Mol file:5499-70-7.mol

Synonyms:5499-70-7;3-methyl-1-phenyl-5-(piperidin-1-yl)-1h-pyrazole-4-carbaldehyde;3-methyl-1-phenyl-5-piperidin-1-yl-1H-pyrazole-4-carbaldehyde;3-methyl-1-phenyl-5-piperidin-1-ylpyrazole-4-carbaldehyde;CBMicro_026744;Cambridge id 5636860;Oprea1_021561;Oprea1_729762;DTXSID00351463;MFCD01124432;STL306460;AKOS000121679;BIM-0026823.P001;CS-0220987;EN300-08079;Z56792908;3-Methyl-1-phenyl-5-piperidin-1-yl-1H-pyrazole-4-carbaldehyde, AldrichCPR

Suppliers and Price of 3-Methyl-1-phenyl-5-(piperidin-1-yl)-1h-pyrazole-4-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-METHYL-1-PHENYL-5-PIPERIDIN-1-YL-1H-PYRAZOLE-4-CARBALDEHYDE 95.00%
5G
$ 1717.07

American Custom Chemicals Corporation
3-METHYL-1-PHENYL-5-PIPERIDIN-1-YL-1H-PYRAZOLE-4-CARBALDEHYDE 95.00%
2.5G
$ 1337.31

American Custom Chemicals Corporation
3-METHYL-1-PHENYL-5-PIPERIDIN-1-YL-1H-PYRAZOLE-4-CARBALDEHYDE 95.00%
1G
$ 910.76

Total 3 raw suppliers

Chemical Property of 3-Methyl-1-phenyl-5-(piperidin-1-yl)-1h-pyrazole-4-carbaldehyde

Chemical Property:

Vapor Pressure:1.54E-08mmHg at 25°C
Boiling Point:457°Cat760mmHg
Flash Point:230.2°C
PSA：38.13000
Density:1.18g/cm³
LogP:3.04850
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:269.152812238
Heavy Atom Count:20
Complexity:324

Purity/Quality:

99% ^*data from raw suppliers

3-METHYL-1-PHENYL-5-PIPERIDIN-1-YL-1H-PYRAZOLE-4-CARBALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NN(C(=C1C=O)N2CCCCC2)C3=CC=CC=C3

Technology Process of 3-Methyl-1-phenyl-5-(piperidin-1-yl)-1h-pyrazole-4-carbaldehyde

There total 4 articles about 3-Methyl-1-phenyl-5-(piperidin-1-yl)-1h-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 110-89-4
piperidine

: 947-95-5
5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

: 5499-70-7
3-methyl-1-phenyl-5-(piperidin-1-yl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: piperidine; With potassium carbonate; In ethanol; at 20 ℃; for 0.5h;

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole; In ethanol; for 2h; Reflux;
DOI:10.1107/S2053229619006752

Reference yield:

: 89-25-8
edaravone

: 5499-70-7
3-methyl-1-phenyl-5-(piperidin-1-yl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate

2: sodium hydride / N,N-dimethyl-formamide / Reflux

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.08.048

Reference yield:

: 100-63-0
phenylhydrazine

: 5499-70-7
3-methyl-1-phenyl-5-(piperidin-1-yl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / ethanol / 8 h / Reflux

2: trichlorophosphate / 2 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / Reflux

With potassium carbonate; acetic acid; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1007/s00044-021-02760-3