Propanamide, N,N-dibutyl-

Base Information

• Chemical Name: Propanamide, N,N-dibutyl-
• CAS No.: 1187-33-3
• Molecular Formula: C₁₁H₂₃NO
• Molecular Weight: 185.31
• Hs Code.: 2924199090
• European Community (EC) Number: 849-613-2
• NSC Number: 12063
• UNII: 0NJ1X32ODA
• DSSTox Substance ID: DTXSID5061582
• Nikkaji Number: J40.757G
• Wikidata: Q81989548
• Mol file: 1187-33-3.mol

Synonyms:N,N-dibutylpropanamide;Propanamide, N,N-dibutyl-;Dibutylpropionamide;1187-33-3;N,N-Dibutylpropionamide;Propionamide, N,N-dibutyl-;NSC 12063;BRN 1763246;0NJ1X32ODA;AI3-02842;NSC-12063;4-04-00-00570 (Beilstein Handbook Reference);N,N-dibutyl-propionamide;NSC12063;Propanamide,N-dibutyl-;Propionamide,N-dibutyl-;UNII-0NJ1X32ODA;SCHEMBL2678053;DTXSID5061582;WLN: 4N4&V2;AKOS003857618;LS-124118;FT-0629446

Chemical Property of Propanamide, N,N-dibutyl-

Chemical Property:

• Vapor Pressure: 0.0268mmHg at 25°C
• Refractive Index: 1.4420 (estimate)
• Boiling Point: 246.6°C at 760 mmHg
• Flash Point: 92.5°C
• PSA: 20.31000
• Density: 0.863g/cm³
• LogP: 2.82520
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 7
• Exact Mass: 185.177964357
• Heavy Atom Count: 13
• Complexity: 126

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-DIBUTYLPROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCN(CCCC)C(=O)CC

Technology Process of Propanamide, N,N-dibutyl-

There total 4 articles about Propanamide, N,N-dibutyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

chloropropionic acid (107-94-8) + dibutylamine (111-92-2) → Ν,Ν-dibutyl-propionamide (1187-33-3)

Guidance literature:

With sodium hydroxide; In water; toluene; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

propionyl chloride (79-03-8) + dibutylamine (111-92-2) → Ν,Ν-dibutyl-propionamide (1187-33-3)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 1h;

DOI:10.1021/jm00355a010

Reference yield:

propionic acid (802294-64-0,79-09-4) → Ν,Ν-dibutyl-propionamide (1187-33-3)

Guidance literature:

With tetrachlorosilane; benzene; und Behandeln des Reaktionsgemisches mit Dibutylamin;

upstream raw materials:

propionic acid

propionyl chloride

dibutylamine

chloropropionic acid

Downstream raw materials:

2-(1-o-chlorophenethyl-4-hydroxy-4-piperidyl)-N,N-dibutyl-propionamide

N,N-Dibutylthiopropionamid

Refernces

• 1、 Huegi, Bruno S.,Ebnoether, Anton M.,Rissi, Erwin,Gadient, Fulvio,Hauser, Daniel,et al.. "Synthesis and Pharmacological Studies of 4,4-Disubstituted Piperidines: A New Class of Compounds with Potent Analgesic Properties". . p. 42 - 50. Retrieved 2007/10/02.