4-(2-Methyl-1,3-thiazol-4-yl)aniline

Base Information

• Chemical Name: 4-(2-Methyl-1,3-thiazol-4-yl)aniline
• CAS No.: 25021-49-2
• Molecular Formula: C10H10N2S
• Molecular Weight: 190.269
• Hs Code.: 2934100090
• European Community (EC) Number: 833-089-7
• DSSTox Substance ID: DTXSID50179730
• Nikkaji Number: J586.509C
• Wikidata: Q83050257
• Mol file: 25021-49-2.mol

Synonyms:2-MAPT;2-methyl-4-(4-aminophenyl)thiazole;2-methyl-4-(para-aminophenyl)thiazole

Chemical Property of 4-(2-Methyl-1,3-thiazol-4-yl)aniline

Chemical Property:

• Vapor Pressure: 5.88E-05mmHg at 25°C
• Melting Point: 133-135 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Refractive Index: 1.642
• Boiling Point: 346.1 °C at 760 mmHg
• PKA: 3.51±0.10(Predicted)
• Flash Point: 163.1 °C
• PSA: 67.15000
• Density: 1.219 g/cm³
• LogP: 3.28190
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 190.05646950
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Methyl-1,3-thiazol-4-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CS1)C2=CC=C(C=C2)N
• Uses: 4-(2-Methyl-1,3-thiazol-4-yl)aniline is used to synthesize and characterize 3''-?(4-?(2-?substituted thiazol-?4-?yl)?phenyl)?spiro[indoline-?3,?2''-?thiazolidine]?-?2,?4''-?diones, which showed good antimicrobial activity.

Technology Process of 4-(2-Methyl-1,3-thiazol-4-yl)aniline

There total 11 articles about 4-(2-Methyl-1,3-thiazol-4-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methyl-4-(4-nitrophenyl)thiazole (33102-81-7) → 4-(2-methylthiazol-4-yl)benzenamine (25021-49-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 5h; under 3000.3 Torr;

Reference yield: 92.0%

N-[4-(2-methyl-4-thiazolyl)phenyl]acetamide (65321-91-7) → 4-(2-methylthiazol-4-yl)benzenamine (25021-49-2)

Guidance literature:

With hydrogenchloride; In ethanol; water; Reflux;

DOI:10.3109/14756366.2012.709242

Reference yield: 92.0%

hydrogenchloride (7647-01-0,15364-23-5) + N-[4-(2-methyl-4-thiazolyl)phenyl]acetamide (65321-91-7) → 4-(2-methylthiazol-4-yl)benzenamine (25021-49-2)

Guidance literature:

for 1h; Reflux;

DOI:10.3906/kim-1312-62

upstream raw materials:

2-methyl-4-(4-nitrophenyl)thiazole

N-[4-(chloroacetyl)phenyl]acetamide

thioacetamide

4-aminophenacyl chloride

Downstream raw materials:

2,2'-[4-(2-methyl-thiazol-4-yl)-phenylazanediyl]-bis-ethanol

N-{4-[bis-(2-chloro-ethyl)-amino]-benzylidene}-4-(2-methyl-thiazol-4-yl)-aniline

1,3-bis-[4-(2-methyl-thiazol-4-yl)-phenyl]-thiourea

1-(4-isopropoxy-phenyl)-3-[4-(2-methyl-thiazol-4-yl)-phenyl]-thiourea