2-methyl-4-(4-nitrophenyl)thiazole

Base Information

• Chemical Name: 2-methyl-4-(4-nitrophenyl)thiazole
• CAS No.: 33102-81-7
• Molecular Formula: C10H8 N2 O2 S
• Molecular Weight: 220.252
• Hs Code.: 2934100090
• Mol file: 33102-81-7.mol

Synonyms:Thiazole,2-methyl-4-(p-nitrophenyl)- (6CI,8CI); 2-Methyl-4-(4-nitrophenyl)thiazole

Chemical Property of 2-methyl-4-(4-nitrophenyl)thiazole

Chemical Property:

• Vapor Pressure: 1.52E-05mmHg at 25°C
• Boiling Point: 376.9°Cat760mmHg
• Flash Point: 181.8°C
• PSA: 86.95000
• Density: 1.33g/cm³
• LogP: 3.54990
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-4-(4-nitrophenyl)-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-4-(4-nitrophenyl)thiazole

There total 11 articles about 2-methyl-4-(4-nitrophenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Nitrophenacyl bromide (99-81-0) + thioacetamide (62-55-5) → 2-methyl-4-(4-nitrophenyl)thiazole (33102-81-7)

Guidance literature:

In ethylene glycol; at 20 ℃; for 0.0833333h;

DOI:10.1080/00397910802691874

Reference yield: 78.0%

2-hydroxy-1-(4-nitrophenyl)ethanone (64611-67-2) + thioacetamide (62-55-5) → 2-methyl-4-(4-nitrophenyl)thiazole (33102-81-7)

Guidance literature:

2-hydroxy-1-(4-nitrophenyl)ethanone; With triethylamine; In dichloromethane; for 24h; Heating;

thioacetamide; With potassium carbonate; In acetonitrile; for 10h; Further stages.; Heating;

DOI:10.1080/00397910802136672

Reference yield: 68.0%

thioacetamide (62-55-5) + (4-nitrophenyl)ethanone (100-19-6) → 2-methyl-4-(4-nitrophenyl)thiazole (33102-81-7)

Guidance literature:

(4-nitrophenyl)ethanone; With polymer-supported [(hydroxy(sulfonyloxy)iodo]benzene; In acetonitrile; for 16h; Heating;

thioacetamide; With potassium carbonate; In acetonitrile; for 6h; Heating;

DOI:10.1055/s-2004-831242

upstream raw materials:

2-methyl-4-phenylthiazole

1-(4-nitrophenyl)-2-(p-tolylsulfonyloxy)ethanone

thioacetamide

(4-nitrophenyl)ethanone

Downstream raw materials:

4-(4-nitro-phenyl)-2-styryl-thiazole

2-(4-methoxy-styryl)-4-(4-nitro-phenyl)-thiazole

4-(2-methylthiazol-4-yl)benzenamine

1-[4-(2-methyl-4-thiazolyl)phenyl]-2(1H,3H)-imidazolone