33102-81-7

Basic information

• Product Name: 2-methyl-4-(4-nitrophenyl)thiazole
• Synonyms: Thiazole, 2-Methyl-4-(4-nitrophenyl)-;2-methyl-4-(4-nitrophenyl)-1,3-thiazole;2-Methyl-4-(para-nitrophenyl)thiazole;2-Mnpt
• CAS NO: 33102-81-7
• Molecular Formula: C₁₀H₈N₂O₂S
• Molecular Weight: 220.25
• Mol File: 33102-81-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 376.9°Cat760mmHg
• Flash Point: 181.8°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 1.52E-05mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-methyl-4-(4-nitrophenyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-(4-nitrophenyl)thiazole(33102-81-7)
• EPA Substance Registry System: 2-methyl-4-(4-nitrophenyl)thiazole(33102-81-7)

Safety Data

• Hazardous Substances Data: 33102-81-7(Hazardous Substances Data)

Usage

General Description

2-methyl-4-(4-nitrophenyl)thiazole is a chemical compound with the molecular formula C11H8N2O2S. It is a thiazole derivative and contains a nitrophenyl group. 2-methyl-4-(4-nitrophenyl)thiazole is often used in the synthesis of pharmaceuticals and agrochemicals due to its versatile properties. It is known for its antimicrobial and antifungal activities, making it valuable in the development of new drugs. Additionally, it has been studied for its potential use in the treatment of various diseases and conditions. Its structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C10H8N2O2S/c1-7-11-10(6-15-7)8-2-4-9(5-3-8)12(13)14/h2-6H,1H3

Upstream product

• 1826-16-0 2-methyl-4-phenylthiazole 
• 62-55-5 thioacetamide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 99-81-0 4-Nitrophenacyl bromide 
• 64611-67-2 2-hydroxy-1-(4-nitrophenyl)ethanone 
• 10342-64-0 p-nitroacetophenone oxime 
• 108-24-7 acetic anhydride 
• 6531-13-1 1-[4-nitrophenyl]-1-ethanol 
• 56177-37-8 1-(4-nitrophenyl)-2-(p-tolylsulfonyloxy)ethanone 

Downstream Products

• 93326-72-8 4-(4-nitro-phenyl)-2-styryl-thiazole 
• 96504-58-4 2-(4-methoxy-styryl)-4-(4-nitro-phenyl)-thiazole 
• 25021-49-2 4-(2-methylthiazol-4-yl)benzenamine 
• 1314976-48-1 Br^(1-)*C₂₈H₂₂N₂O₂PS⁽¹⁺⁾ 
• 1314976-49-2 C₂₁H₂₁N₃O₄S 
• 1314976-45-8 C₁₀H₇BrN₂O₂S 
• 1229014-76-9 2-[4-(2-methylthiazol-4-yl)phenylamino]-6-(methylamino)-3-nitropyridine 
• 1229016-75-4 2-[4-(2-methylthiazol-4-yl)phenylamino]-6-chloro-3-nitropyridine 
• 942920-44-7 5-bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole 
• 25020-75-1 1,3-bis-[4-(2-methyl-thiazol-4-yl)-phenyl]-thiourea 
• 7021-82-1 1-[4-(2-methyl-thiazol-4-yl)-phenyl]-3-(4-pentyloxy-phenyl)-thiourea 
• 7021-80-9 1-(4-butoxy-phenyl)-3-[4-(2-methyl-thiazol-4-yl)-phenyl]-thiourea 
• 7021-81-0 1-(4-isobutoxy-phenyl)-3-[4-(2-methyl-thiazol-4-yl)-phenyl]-thiourea 
• 7021-79-6 1-(4-isopropoxy-phenyl)-3-[4-(2-methyl-thiazol-4-yl)-phenyl]-thiourea 

Relevant articles and documents

Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N-O/C-S bond cleavages, activation of vinyl sp2 C-H bond, and C-S/C-N bond formations which are under redox-neutral conditions as well as operational simplicity.

Lipase and deep eutectic mixture catalyzed efficient synthesis of thiazoles in water at room temperature

Lipase bio-catalyst or ammonium based deep eutectic mixture efficiently catalyzed aqueous phase synthesis of methyl-thiazole and amino-thiazole derivatives. The simple ammonium deep eutectic catalyst, easily synthesized from choline chloride and urea, is inexpensive, recyclable and bio-degradable, making it suitable for industrial applications. Springer Science+Business Media, LLC 2012.

NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME

The present invention relates to a novel 2,6-substituted-3-nitropyridine derivative compound, a method for preparing the same, and a pharmaceutical composition including the same for prevention and treatment of osteoporosis. The 2,6-substituted-3-nitropyr