2-(4-Methoxyphenoxy)ethanol

Base Information

• Chemical Name: 2-(4-Methoxyphenoxy)ethanol
• CAS No.: 5394-57-0
• Molecular Formula: C9H12 O3
• Molecular Weight: 168.192
• Hs Code.: 2909499000
• European Community (EC) Number: 653-717-1
• NSC Number: 2329
• DSSTox Substance ID: DTXSID00277432
• Nikkaji Number: J211.580H
• Wikidata: Q82008585
• ChEMBL ID: CHEMBL74201
• Mol file: 5394-57-0.mol

Synonyms:2-(4-Methoxyphenoxy)ethanol;5394-57-0;2-(4-methoxyphenoxy)ethan-1-ol;2-(4-Methoxyphenoxy)-1-ethanol;2-(4'-Methoxyphenoxy)ethanol;Ethanol, 2-(4-methoxyphenoxy)-;Ethanol, 2-[4-methoxyphenoxy]-;NSC2329;SCHEMBL77535;CHEMBL74201;DTXSID00277432;NSC 2329;NSC-2329;Butanoic acid, 2-naphthalenyl ester;MFCD00016568;STL444067;AKOS000296373;SB84002;SS-2122;FT-0681250;1-(2-HYDROXYETHOXY)-4-METHOXYBENZENE;E89332;J-506036

Chemical Property of 2-(4-Methoxyphenoxy)ethanol

Chemical Property:

• Vapor Pressure: 0.000765mmHg at 25°C
• Boiling Point: 293.8°Cat760mmHg
• Flash Point: 131.5°C
• PSA: 38.69000
• Density: 1.11g/cm³
• LogP: 1.06630
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Methoxyphenoxy)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)OCCO
• Uses: 2-(4-Methoxyphenoxy)ethanol is a useful compound for preparation of benzannulated and spirobenzannulated compounds.

Technology Process of 2-(4-Methoxyphenoxy)ethanol

There total 14 articles about 2-(4-Methoxyphenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxyphenoxyethyl tetrahydro-2H-pyran-2-yl ether (191331-97-2) → 2-(4-methoxyphenoxy)ethanol (5394-57-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 23 ℃; for 16h;

DOI:10.1016/j.bmc.2019.02.039

Reference yield: 93.0%

1-bromo-4-methoxy-benzene (104-92-7) + ethylene glycol (107-21-1) → 2-(4-methoxyphenoxy)ethanol (5394-57-0)

Guidance literature:

With potassium carbonate; copper dichloride; at 130 ℃; for 20h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4ob00649f

Reference yield: 90.0%

8-tert-Butyl-8-methoxy-1,4-dioxa-spiro[4.5]deca-6,9-diene (110391-92-9) → 2-(4-methoxyphenoxy)ethanol (5394-57-0)

Guidance literature:

With hydrogenchloride; at 0 ℃;

DOI:10.1039/c39870000610

upstream raw materials:

4-methoxy-phenol

2-chloro-ethanol

[1,3]-dioxolan-2-one

ethyl (4-methoxyphenoxy)acetate

Downstream raw materials:

Ethylene dimethyl bisketal of benzoquinone

2-(1,4,4-Trimethoxy-cyclohexa-2,5-dienyloxy)-ethanol

Sodium; (4-methoxy-phenoxy)-acetate

2'-(4-methoxy-3-nitrophenoxy)ethanol